Hallmarks Of exosomes

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2021 Dec 13

PMID 34900338

Citations 11

Authors

Nihat Dilsiz

Affiliations

Soon will be listed here.

Abstract

Exosomes are a new horizon in modern therapy, presenting exciting new opportunities for advanced drug delivery and targeted release. Exosomes are small extracellular vesicles with a size range of 30-100 nm, secreted by all cell types in the human body and carrying a unique collection of DNA fragments, RNA species, lipids, protein biomarkers, transcription factors and metabolites. miRNAs are one of the most common RNA species in exosomes, and they play a role in a variety of biological processes including exocytosis, hematopoiesis and angiogenesis, as well as cellular communication via exosomes. Exosomes can act as cargo to transport this information from donor cells to near and long-distance target cells, participating in the reprogramming of recipient cells.

Citing Articles

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Role of Exosomes in Salivary Gland Tumors and Technological Advances in Their Assessment.

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References

Umezu T, Tadokoro H, Azuma K, Yoshizawa S, Ohyashiki K, Ohyashiki J . Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1. Blood. 2014; 124(25):3748-57. PMC: 4263983. DOI: 10.1182/blood-2014-05-576116. View

Gokita K, Inoue J, Ishihara H, Kojima K, Inazawa J . Therapeutic Potential of LNP-Mediated Delivery of miR-634 for Cancer Therapy. Mol Ther Nucleic Acids. 2019; 19:330-338. PMC: 6938807. DOI: 10.1016/j.omtn.2019.10.045. View

Tomasetti M, Lee W, Santarelli L, Neuzil J . Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy. Exp Mol Med. 2017; 49(1):e285. PMC: 5291842. DOI: 10.1038/emm.2016.153. View

Moutinho C, Esteller M . MicroRNAs and Epigenetics. Adv Cancer Res. 2017; 135:189-220. DOI: 10.1016/bs.acr.2017.06.003. View

Sento S, Sasabe E, Yamamoto T . Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes. PLoS One. 2016; 11(2):e0148454. PMC: 4743844. DOI: 10.1371/journal.pone.0148454. View

Zhang Y, Liu Y, Liu H, Tang W . Exosomes: biogenesis, biologic function and clinical potential. Cell Biosci. 2019; 9:19. PMC: 6377728. DOI: 10.1186/s13578-019-0282-2. View

ONeill S, ODriscoll L . Profiling Circulating miRNAs from the Plasma of Individuals with Metabolic Syndrome. Methods Mol Biol. 2016; 1509:141-149. DOI: 10.1007/978-1-4939-6524-3_13. View

Barile L, Vassalli G . Exosomes: Therapy delivery tools and biomarkers of diseases. Pharmacol Ther. 2017; 174:63-78. DOI: 10.1016/j.pharmthera.2017.02.020. View

Clancy J, DSouza-Schorey C . Extracellular Vesicles in Cancer: Purpose and Promise. Cancer J. 2018; 24(2):65-69. PMC: 6645395. DOI: 10.1097/PPO.0000000000000306. View

10.

Aqil F, Munagala R, Jeyabalan J, Agrawal A, Gupta R . Exosomes for the Enhanced Tissue Bioavailability and Efficacy of Curcumin. AAPS J. 2017; 19(6):1691-1702. DOI: 10.1208/s12248-017-0154-9. View

11.

van der Pol E, Coumans F, Grootemaat A, Gardiner C, Sargent I, Harrison P . Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing. J Thromb Haemost. 2014; 12(7):1182-92. DOI: 10.1111/jth.12602. View

12.

Wang Y, Xu Y, Zou Y, Lin J, Huang B, Liu J . Identification of differential expressed PE exosomal miRNA in lung adenocarcinoma, tuberculosis, and other benign lesions. Medicine (Baltimore). 2017; 96(44):e8361. PMC: 5682784. DOI: 10.1097/MD.0000000000008361. View

13.

Kim H, Lee G, Ganat Y, Papapetrou E, Lipchina I, Socci N . miR-371-3 expression predicts neural differentiation propensity in human pluripotent stem cells. Cell Stem Cell. 2011; 8(6):695-706. DOI: 10.1016/j.stem.2011.04.002. View

14.

Stevic I, Muller V, Weber K, Fasching P, Karn T, Marme F . Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the GeparSixto trial. BMC Med. 2018; 16(1):179. PMC: 6178264. DOI: 10.1186/s12916-018-1163-y. View

15.

Aleckovic M, McAllister S, Polyak K . Metastasis as a systemic disease: molecular insights and clinical implications. Biochim Biophys Acta Rev Cancer. 2019; 1872(1):89-102. PMC: 6692219. DOI: 10.1016/j.bbcan.2019.06.002. View

16.

Samanta S, Rajasingh S, Drosos N, Zhou Z, Dawn B, Rajasingh J . Exosomes: new molecular targets of diseases. Acta Pharmacol Sin. 2017; 39(4):501-513. PMC: 5888687. DOI: 10.1038/aps.2017.162. View

17.

Romagnoli G, Zelante B, Toniolo P, Migliori I, Barbuto J . Dendritic Cell-Derived Exosomes may be a Tool for Cancer Immunotherapy by Converting Tumor Cells into Immunogenic Targets. Front Immunol. 2015; 5:692. PMC: 4298225. DOI: 10.3389/fimmu.2014.00692. View

18.

Gutierrez-Millan C, Calvo Diaz C, Lanao J, Colino C . Advances in Exosomes-Based Drug Delivery Systems. Macromol Biosci. 2020; 21(1):e2000269. DOI: 10.1002/mabi.202000269. View

19.

Dong H, Chen H, Jiang J, Zhang H, Cai C, Shen Q . Highly Sensitive Electrochemical Detection of Tumor Exosomes Based on Aptamer Recognition-Induced Multi-DNA Release and Cyclic Enzymatic Amplification. Anal Chem. 2018; 90(7):4507-4513. DOI: 10.1021/acs.analchem.7b04863. View

20.

Yao Q, Chen Y, Zhou X . The roles of microRNAs in epigenetic regulation. Curr Opin Chem Biol. 2019; 51:11-17. DOI: 10.1016/j.cbpa.2019.01.024. View