Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches

Overview

Journal Front Pharmacol

Date 2021 Dec 13

PMID 34899283

Citations 5

Authors

C Batson

A Gomez

A S Sainbhi

L Froese

F A Zeiler

Affiliations

Soon will be listed here.

Abstract

The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the association between age/biological sex and high-frequency continuous multi-modal monitoring (MMM) cerebral physiology is unclear, with only sparing reference made in guidelines and major literature in moderate/severe TBI. In this narrative review, we summarize some of the largest studies associating various high-frequency MMM parameters with age and biological sex in moderate/severe TBI. To start, we present this by highlighting the representative available literature on high-frequency data from Intracranial Pressure (ICP), Cerebral Perfusion Pressure (CPP), Extracellular Brain Tissue Oxygenation (PbtO), Regional Cerebral Oxygen Saturations (rSO), Cerebral Blood Flow (CBF), Cerebral Blood Flow Velocity (CBFV), Cerebrovascular Reactivity (CVR), Cerebral Compensatory Reserve, common Cerebral Microdialysis (CMD) Analytes and their correlation to age and sex in moderate/severe TBI cohorts. Then we present current knowledge gaps in the literature, discuss biological implications of age and sex on cerebrovascular monitoring in TBI and some future avenues for bedside research into the cerebrovascular physiome after TBI.

Citing Articles

Discrete Fourier Transform Windowing Techniques for Cerebral Physiological Research in Neural Injury: A Practical Demonstration.

Froese L, Sainbhi A, Gomez A, Marquez I, Amenta F, Batson C Neurotrauma Rep. 2023; 4(1):410-419.

PMID: 37360544 PMC: 10288301. DOI: 10.1089/neur.2022.0079.

The establishment and validation of a prediction model for traumatic intracranial injury patients: a reliable nomogram.

Chen J, Jin G, Zeng L, Ma B, Chen H, Gu N Front Neurol. 2023; 14:1165020.

PMID: 37305757 PMC: 10249071. DOI: 10.3389/fneur.2023.1165020.

Temporal relationship between vasopressor and sedative administration and cerebrovascular response in traumatic brain injury: a time-series analysis.

Froese L, Gomez A, Sainbhi A, Vakitbilir N, Marquez I, Amenta F Intensive Care Med Exp. 2023; 11(1):30.

PMID: 37246179 PMC: 10225391. DOI: 10.1186/s40635-023-00515-5.

Associations between intracranial pressure thresholds and multimodal monitoring in acute traumatic neural injury: a scoping review.

Stein K, Amenta F, Gomez A, Froese L, Sainbhi A, Vakitbilir N Acta Neurochir (Wien). 2023; 165(7):1987-2000.

PMID: 37067617 DOI: 10.1007/s00701-023-05587-6.

Association between cerebrovascular reactivity in adult traumatic brain injury and improvement in patient outcome over time: an exploratory analysis.

Stein K, Froese L, Gomez A, Sainbhi A, Batson C, Mathieu F Acta Neurochir (Wien). 2022; 164(12):3107-3118.

PMID: 36156746 DOI: 10.1007/s00701-022-05366-9.

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