Microglia in Alzheimer's Disease: A Target for Therapeutic Intervention

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2021 Dec 13

PMID 34899188

Citations 39

Authors

Guimei Zhang

Zicheng Wang

Huiling Hu

Meng Zhao

Li Sun

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is one of the most common types of age-related dementia worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary tangles, dysregulated microglia also play deleterious roles in the AD pathogenesis. Numerous studies have demonstrated that unbridled microglial activity induces a chronic neuroinflammatory environment, promotes β-amyloid accumulation and tau pathology, and impairs microglia-associated mitophagy. Thus, targeting microglia may pave the way for new therapeutic interventions. This review provides a thorough overview of the pathophysiological role of the microglia in AD and illustrates the potential avenues for microglia-targeted therapies, including microglial modification, immunoreceptors, and anti-inflammatory drugs.

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