Impact of Chronic Kidney Disease on the Prognosis of Transcatheter Aortic Valve Replacement in Patients with Aortic Stenosis: A Meta-Analysis of 133624 Patients

Overview

Journal Ann Thorac Cardiovasc Surg

Specialties Cardiology & Vascular Diseases
General Surgery
Pulmonary Medicine

Date 2021 Dec 13

PMID 34897184

Citations 4

Authors

Jialu Wang

Shidong Liu

Xiangxiang Han

Yang Chen

Hao Chen

Shuai Dong

Bing Song

Affiliations

Soon will be listed here.

Abstract

Purpose: The impact of chronic kidney disease (CKD) on the prognosis of transcatheter aortic valve replacement (TAVR) remains unclear. The purpose of this meta-analysis was to assess the impact of CKD and different stages of CKD on prognosis in patients undergoing TAVR.

Methods: As of June 2020, we performed a comprehensive literature search on relevant studies using PubMed, Embase, Cochrane Library, and Web of Science. Subsequently, we pooled the risk ratio (RR) of individual studies via random effects to analyze heterogeneity, quality assessment, and publication bias.

Results: A total of 20 studies, involving 133624 patients, were eligible for analysis. Patients with CKD had higher all-cause mortality at 30 days (RR: 1.39, 95% confidence interval [CI]: 1.31-1.47, P <0.001), 1 year (RR: 1.36, 95% CI: 1.24-1.49, P <0.001), and 2 years (RR: 1.2, 95% CI: 1.05-1.38, P = 0.009) of follow-up. Moreover, they also had higher acute kidney injury (AKI) (RR: 1.38, 95% CI: 1.16-1.63, P <0.001) and bleeding (RR: 1.33, 95% CI: 1.18-1.50, P <0.001) at 30 days. CKD3 alone also increased all-cause mortality at follow-ups. Risk of all-cause mortality increased with severity of CKD for stages 3, 4, and 5 at follow-up.

Conclusion: Patients with CKD are at an increased risk of all-cause mortality, AKI, and bleeding events after TAVR. Moreover, the mortality risk rises with increasing severity of CKD.

Citing Articles

Aortic Stenosis and the Evolution of Cardiac Damage after Transcatheter Aortic Valve Replacement.

Islas F, ONeill-Gonzalez P, Jimenez-Quevedo P, Nombela-Franco L, Gil-Abizanda S, Mahia-Casado P J Clin Med. 2024; 13(12).

PMID: 38930068 PMC: 11204698. DOI: 10.3390/jcm13123539.

In-hospital outcomes of transcatheter aortic valve replacement in patients with chronic and end-stage renal disease: a nationwide database study.

Lorente-Ros M, Das S, Malik A, Romeo F, Aguilar-Gallardo J, Fakhoury M BMC Cardiovasc Disord. 2024; 24(1):21.

PMID: 38172786 PMC: 10765730. DOI: 10.1186/s12872-023-03684-z.

Cardiovascular Calcification Heterogeneity in Chronic Kidney Disease.

Hutcheson J, Goettsch C Circ Res. 2023; 132(8):993-1012.

PMID: 37053279 PMC: 10097496. DOI: 10.1161/CIRCRESAHA.123.321760.

Technical Success after Transcatheter Aortic Valve Replacement for Bicuspid versus Tricuspid Aortic Stenosis.

Dai H, Fan J, He Y, Chen J, Zhou D, Yidilisi A J Clin Med. 2023; 12(1).

PMID: 36615142 PMC: 9821499. DOI: 10.3390/jcm12010343.

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