Influence of Incorporation of Different D-Electron Metal Cations into Biologically Active System on Its Biological and Physicochemical Properties

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Dec 10

PMID 34884712

Citations 1

Authors

Bartlomiej Rogalewicz

Malgorzata Szczesio

Ewa Poleszak

Joanna Kowalczyk

Bernadeta Szewczyk

Bruno Cury Camargo

Jacek Szczytko

Marcin Witkowski

Andrzej Fruzinski

Anita Raducka

Robert Banasiak

Agnieszka Czylkowska

Affiliations

Soon will be listed here.

Abstract

Three new compounds, namely [HL][CuCl], [HL][ZnCl], and [HL][CdCl] () were synthesized and their physicochemical and biological properties were thoroughly investigated. All three compounds form isostructural, crystalline systems, which have been studied using Single-Crystal X-ray diffraction analysis (SC-XRD) and Fourier-transform infrared spectroscopy (FTIR). The thermal stability was investigated using thermogravimetric analysis (TGA) and melting points for all compounds have been determined. Magnetic measurements were performed in order to study the magnetic properties of the compounds. The above mentioned techniques allowed us to comprehensively examine the physicochemical properties of the newly obtained compounds. The biological activity was investigated using the number of Zebrafish tests, as it is one of the most common models for studying the impact of newly synthesized compounds on the central nervous system (CNS), since this model is very similar to the human CNS.

Citing Articles

Evaluation of Antidepressive-like Behaviours and Oxidative Stress Parameters in Mice Receiving Imipramine-Zinc Complex Compound.

Szopa A, Herbet M, Poleszak E, Serefko A, Czylkowska A, Piatkowska-Chmiel I Int J Mol Sci. 2023; 24(18).

PMID: 37762458 PMC: 10531591. DOI: 10.3390/ijms241814157.

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