Microbiome-Friend or Foe of Pancreatic Cancer?

Overview

Journal J Clin Med

Specialty General Medicine

Date 2021 Dec 10

PMID 34884327

Citations 3

Authors

Jaroslaw Daniluk

Urszula Daniluk

Pawel Rogalski

Andrzej Dabrowski

Agnieszka Swidnicka-Siergiejko

Affiliations

Soon will be listed here.

Abstract

Pancreatic ductal adenocarcinoma is one of the deadliest human neoplasms. Despite the development of new surgical and adjuvant therapies, the prognosis remains very poor, with the overall survival rate not exceeding 9%. There is now increasing evidence that the human microbiome, which is involved in many physiological functions, including the regulation of metabolic processes and the modulation of the immune system, is possibly linked to pancreatic oncogenesis. However, the exact mechanisms of action are poorly understood. Our review summarizes the current understanding of how the microbiome affects pancreatic cancer development and progression. We discuss potential pathways of microbe translocation to the pancreas, as well as the mechanism of their action. We describe the role of the microbiome as a potential marker of pancreatic cancer diagnosis, progression, and survival. Finally, we discuss the possibilities of modifying the microbiome to improve treatment effectiveness for this deadly disease.

Citing Articles

Inflammatory Stimuli and Fecal Microbiota Transplantation Accelerate Pancreatic Carcinogenesis in Transgenic Mice, Accompanied by Changes in the Microbiota Composition.

Swidnicka-Siergiejko A, Daniluk J, Miniewska K, Daniluk U, Guzinska-Ustymowicz K, Pryczynicz A Cells. 2025; 14(5).

PMID: 40072088 PMC: 11898920. DOI: 10.3390/cells14050361.

Inflammation, microbiota, and pancreatic cancer.

Chen X, Sun F, Wang X, Feng X, Aref A, Tian Y Cancer Cell Int. 2025; 25(1):62.

PMID: 39987122 PMC: 11847367. DOI: 10.1186/s12935-025-03673-6.

Microbial Biomarkers in Liquid Biopsy for Cancer: An Overview and Future Directions.

Luo F, Wang X, Ye C, Sun H Cancer Control. 2024; 31:10732748241292019.

PMID: 39431347 PMC: 11500238. DOI: 10.1177/10732748241292019.

Microbiome and MicroRNA or Long Non-Coding RNA-Two Modern Approaches to Understanding Pancreatic Ductal Adenocarcinoma.

Izdebska W, Daniluk J, Niklinski J J Clin Med. 2023; 12(17).

PMID: 37685710 PMC: 10488817. DOI: 10.3390/jcm12175643.

Impact of microbiota-immunity axis in pancreatic cancer management.

Bartolini I, Nannini G, Risaliti M, Matarazzo F, Moraldi L, Ringressi M World J Gastroenterol. 2022; 28(32):4527-4539.

PMID: 36157926 PMC: 9476869. DOI: 10.3748/wjg.v28.i32.4527.

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