Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2021 Dec 10

PMID 34883761

Citations 24

Authors

Sayan Ganguly

Shlomo Margel

Affiliations

Soon will be listed here.

Abstract

Hydrogels are spatially organized hydrophilic polymeric systems that exhibit unique features in hydrated conditions. Among the hydrogel family, composite hydrogels are a special class that are defined as filler-containing systems with some tailor-made properties. The composite hydrogel family includes magnetic-nanoparticle-integrated hydrogels. Magnetic hydrogels (MHGs) show magneto-responsiveness, which is observed when they are placed in a magnetic field (static or oscillating). Because of their tunable porosity and internal morphology they can be used in several biomedical applications, especially diffusion-related smart devices. External stimuli may influence physical and chemical changes in these hydrogels, particularly in terms of volume and shape morphing. One of the most significant external stimuli for hydrogels is a magnetic field. This review embraces a brief overview of the fabrication of MHGs and two of their usages in the biomedical area: drug delivery and hyperthermia-based anti-cancer activity. As for the saturation magnetization imposed on composite MHGs, they are easily heated in the presence of an alternating magnetic field and the temperature increment is dependent on the magnetic nanoparticle concentration and exposure time. Herein, we also discuss the mode of different therapies based on non-contact hyperthermia heating.

Citing Articles

Magnetic Polymeric Conduits in Biomedical Applications.

Ganguly S, Margel S Micromachines (Basel). 2025; 16(2).

PMID: 40047623 PMC: 11857720. DOI: 10.3390/mi16020174.

Magnetic Nanoparticles and Drug Delivery Systems for Anti-Cancer Applications: A Review.

Graham W, Torbett-Dougherty M, Islam A, Soleimani S, Bruce-Tagoe T, Johnson J Nanomaterials (Basel). 2025; 15(4).

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Hydrogel-based nanoparticles: revolutionizing brain tumor treatment and paving the way for future innovations.

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Fundamentals and Advances in Stimuli-Responsive Hydrogels and Their Applications: A Review.

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Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review.

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