Relationship Between the SFlt-1/PlGF Ratio and the Optical Coherence Tomographic Features of Chorioretina in Patients with Preeclampsia

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2021 Dec 9

PMID 34882742

Citations 1

Authors

Jaekyoung Lee

Jin Gon Bae

Yu Cheol Kim

Affiliations

Soon will be listed here.

Abstract

This study aimed to evaluate the correlation between ophthalmologic factors and the serologic indicator soluble fms-like tyrosine kinase 1 (sFlt-1): placental growth factor (PlGF) ratio in patients with preeclampsia using optical coherence tomography (OCT) and OCT angiography (OCT-A). A total of 52 pregnant patients (104 eyes) diagnosed with preeclampsia were recruited during their hospital stay. The associations between the sFlt-1/PlGF ratio and chorioretinal measurements, including the choroidal thickness (CT), foveal avascular zone, vascular density, and ganglion cell layer+ were evaluated. Central and nasal subfield CT of the left eye (p = 0.039; p = 0.010) and nasal subfield CT of the right eye (p = 0.042) were lower in the high sFlt-1/PlGF ratio group (≥38). Pearson's correlation test showed a negative correlation between the sFlt-1/PlGF ratio and central subfield CT; however, this was not statistically significant (p = 0.648). Linear regression analysis revealed a significant association between the sFlt-1/PlGF ratio and central subfield CT (β coefficient, -6.66; p = 0.01) and between sFlt-1 and central subfield CT (β coefficient, -5.65; p = 0.00). Thus, an increase in the sFlt-1/PlGF ratio resulted in a decrease in central subfield CT.

Citing Articles

Relationship between proteinuria and changes in antepartum and postpartum choroidal thickness in patients with pre-eclampsia.

Lee Y, Kim D, Bae J, Kim Y Sci Rep. 2024; 14(1):12672.

PMID: 38830948 PMC: 11148149. DOI: 10.1038/s41598-024-63359-3.

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