Development of Biomarkers for Radiation Biodosimetry and Medical Countermeasures Research: Current Status, Utility, and Regulatory Pathways

Overview

Journal Radiat Res

Specialties Genetics
Radiology

Date 2021 Dec 8

PMID 34879151

Citations 16

Authors

Merriline M Satyamitra

Andrea L DiCarlo

Brynn A Hollingsworth

Thomas A Winters

Lanyn P Taliaferro

Affiliations

Soon will be listed here.

Abstract

Biomarkers are important indicators of biological processes in health or disease. For this reason, they play a critical role in advanced development of radiation biodosimetry tools and medical countermeasures (MCMs). They can aid in the assessment of radiation exposure level, extent of radiation-induced injury, and/or efficacy of a MCM. This meeting report summarizes the presentations and discussions from the 2020 workshop titled, "Biomarkers in Radiation Biodosimetry and Medical Countermeasures" sponsored by the Radiation and Nuclear Countermeasures Program (RNCP) within the National Institute of Allergy and Infectious Diseases (NIAID). The main goals of this meeting were to: 1. Provide an overview on biomarkers and to focus on the state of science with regards to biomarkers specific to radiation biodosimetry and MCMs; 2. Understand developmental challenges unique to the role of biomarkers in the fields of radiation biodosimetry and MCM development; and 3. Identify existing gaps and needs for translational application.

Citing Articles

Validation of a blood biomarker panel for machine learning-based radiation biodosimetry in juvenile and adult C57BL/6 mice.

Nemzow L, Phillippi M, Kanagaraj K, Shuryak I, Taveras M, Wu X Sci Rep. 2024; 14(1):23872.

PMID: 39396080 PMC: 11470949. DOI: 10.1038/s41598-024-74953-w.

Biodosimetry, can it find its way to the nuclear medicine clinic?.

Bolcaen J, Combrink N, Spoormans K, More S, Vandevoorde C, Fisher R Front Nucl Med. 2024; 3:1209823.

PMID: 39355046 PMC: 11440959. DOI: 10.3389/fnume.2023.1209823.

BAX and DDB2 as biomarkers for acute radiation exposure in the human blood ex vivo and non-human primate models.

Kanagaraj K, Phillippi M, Ober E, Shuryak I, Kleiman N, Olson J Sci Rep. 2024; 14(1):19345.

PMID: 39164366 PMC: 11336173. DOI: 10.1038/s41598-024-69852-z.

Impact of Partial Body Shielding from Very High Dose Rates on Untargeted Metabolomics in Biodosimetry.

Pannkuk E, Laiakis E, Garty G, Bansal S, Jayatilake M, Tan Y ACS Omega. 2024; 9(32):35182-35196.

PMID: 39157112 PMC: 11325421. DOI: 10.1021/acsomega.4c05688.

Microfluidic measurement of intracellular mRNA with a molecular beacon probe towards point-of-care radiation triage.

Meng X, Wen K, Zhao J, Han Y, Ghandhi S, Kaur S Sens Diagn. 2024; 3(8):1344-1352.

PMID: 39129862 PMC: 11308381. DOI: 10.1039/d4sd00079j.

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