Protection and Rebuilding of the Endothelial Glycocalyx in Sepsis - Science or Fiction?

Overview

Journal Matrix Biol Plus

Date 2021 Dec 8

PMID 34877522

Citations 13

Authors

Carolin Christina Drost

Alexandros Rovas

Philipp Kumpers

Affiliations

Soon will be listed here.

Abstract

The endothelial glycocalyx (eGC), a delicate carbohydrate-rich structure lining the luminal surface of the vascular endothelium, is vital for maintenance of microvascular homeostasis. In sepsis, damage of the eGC triggers the development of vascular hyperpermeability with consecutive edema formation and organ failure. While there is evidence that protection or rebuilding of the eGC might counteract sepsis-induced vascular leakage and improve outcome, approved therapeutics are not yet available. This narrative review aims to outline possible therapeutic strategies to ameliorate organ dysfunction caused by eGC impairment.

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