Perspectives of Glycemic Variability in Diabetic Neuropathy: a Comprehensive Review

Overview

Journal Commun Biol

Specialty Biology

Date 2021 Dec 8

PMID 34876671

Citations 14

Authors

Xiaochun Zhang

Xue Yang

Bao Sun

Chunsheng Zhu

Affiliations

Soon will be listed here.

Abstract

Diabetic neuropathy is one of the most prevalent chronic complications of diabetes, and up to half of diabetic patients will develop diabetic neuropathy during their disease course. Notably, emerging evidence suggests that glycemic variability is associated with the pathogenesis of diabetic complications and has emerged as a possible independent risk factor for diabetic neuropathy. In this review, we describe the commonly used metrics for evaluating glycemic variability in clinical practice and summarize the role and related mechanisms of glycemic variability in diabetic neuropathy, including cardiovascular autonomic neuropathy, diabetic peripheral neuropathy and cognitive impairment. In addition, we also address the potential pharmacological and non-pharmacological treatment methods for diabetic neuropathy, aiming to provide ideas for the treatment of diabetic neuropathy.

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