Computing the Daily Reproduction Number of COVID-19 by Inverting the Renewal Equation Using a Variational Technique

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2021 Dec 8

PMID 34876517

Citations 15

Authors

Luis Alvarez

Miguel Colom

Jean-David Morel

Jean-Michel Morel

Affiliations

Soon will be listed here.

Abstract

The COVID-19 pandemic has undergone frequent and rapid changes in its local and global infection rates, driven by governmental measures or the emergence of new viral variants. The reproduction number indicates the average number of cases generated by an infected person at time and is a key indicator of the spread of an epidemic. A timely estimation of is a crucial tool to enable governmental organizations to adapt quickly to these changes and assess the consequences of their policies. The EpiEstim method is the most widely accepted method for estimating But it estimates with a significant temporal delay. Here, we propose a method, EpiInvert, that shows good agreement with EpiEstim, but that provides estimates of several days in advance. We show that can be estimated by inverting the renewal equation linking with the observed incidence curve of new cases, Our signal-processing approach to this problem yields both and a restored corrected for the "weekend effect" by applying a deconvolution and denoising procedure. The implementations of the EpiInvert and EpiEstim methods are fully open source and can be run in real time on every country in the world and every US state.

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