Oxygen-sensing Mechanisms in Development and Tissue Repair

Overview

Journal Development

Specialty Biology

Date 2021 Dec 7

PMID 34874450

Citations 7

Authors

Yida Jiang

Li-Juan Duan

Guo-Hua Fong

Affiliations

Soon will be listed here.

Abstract

Under normoxia, hypoxia inducible factor (HIF) α subunits are hydroxylated by PHDs (prolyl hydroxylase domain proteins) and subsequently undergo polyubiquitylation and degradation. Normal embryogenesis occurs under hypoxia, which suppresses PHD activities and allows HIFα to stabilize and regulate development. In this Primer, we explain molecular mechanisms of the oxygen-sensing pathway, summarize HIF-regulated downstream events, discuss loss-of-function phenotypes primarily in mouse development, and highlight clinical relevance to angiogenesis and tissue repair.

Citing Articles

Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8.

Hertzog N, Duman M, Bochud M, Brugger-Verdon V, Gerhards M, Schon F Nat Commun. 2025; 16(1):515.

PMID: 39779705 PMC: 11711395. DOI: 10.1038/s41467-025-55835-9.

Myocardial mRNA expression of interleukin-6 and hypoxia inducible factor-1α in neonates with congenital cardiac defects.

Farhat N, Vazquez-Jimenez J, Heying R, Seghaye M Mol Cell Pediatr. 2024; 11(1):14.

PMID: 39708201 PMC: 11663211. DOI: 10.1186/s40348-024-00187-5.

PHD2 safeguards modest mesendoderm development.

Li M, Jin H, Zhao Y, Zhu G, Liu Y, Long H Commun Biol. 2024; 7(1):1100.

PMID: 39244636 PMC: 11380689. DOI: 10.1038/s42003-024-06824-z.

Endothelial HIF2α suppresses retinal angiogenesis in neonatal mice by upregulating NOTCH signaling.

Duan L, Jiang Y, Fong G Development. 2024; 151(11).

PMID: 38770916 PMC: 11190433. DOI: 10.1242/dev.202802.

Oxygen is an essential gasotransmitter directly sensed via protein gasoreceptors.

Anbalagan S Animal Model Exp Med. 2024; 7(2):189-193.

PMID: 38529771 PMC: 11079153. DOI: 10.1002/ame2.12400.

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