Telomere Length in Healthy Newborns is Not Affected by Adverse Intrauterine Environments

Overview

Journal Genet Mol Biol

Specialty Genetics

Date 2021 Dec 7

PMID 34874050

Authors

Monique Cabral Hahn

Isabel Cristina Ribas Werlang

Ciliana Rechenmacher

Rahuany Velleda de Morais

Florencia Maria Barbe-Tuana

Lucas Kich Grun

Fatima Theresinha Costa Rodrigues Guma

Clecio Homrich da Silva

Juliana Rombaldi Bernardi

Mariana Bohns Michalowski

Marcelo Zubaran Goldani

Affiliations

Soon will be listed here.

Abstract

Different intrauterine exposures are associated with different metabolic profiles leading to growth and development characteristics in children and also relate to health and disease patterns in adult life. The objective of this work was to evaluate the impact of four different intrauterine environments on the telomere length of newborns. This is a longitudinal observational study using a convenience sample of 222 mothers and their term newborns (>37 weeks of gestational age) from hospitals in Porto Alegre, Rio Grande do Sul (Brazil), from September 2011 to January 2016. Sample was divided into four groups: pregnant women with Gestational Diabetes Mellitus (DM) (n=38), smoking pregnant women (TOBACCO) (n=52), mothers with small-for-gestational age (SGA) children due to idiopathic intrauterine growth restriction (n=33), and a control group (n=99). Maternal and newborn genomic DNA were obtained from epithelial mucosal cells. Telomere length was assessed by qPCR, with the calculation of the telomere and single copy gene (T/S ratio). In this sample, there was no significant difference in telomere length between groups (p>0.05). There was also no association between childbirth weight and telomere length in children (p>0.05). For term newborns different intrauterine environments seems not to influence telomere length at birth.

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