From Development to Cancer - an Ever-increasing Role of AGR2

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2021 Dec 7

PMID 34873459

Citations 16

Authors

Daria Jach

Yuzhu Cheng

Filip Prica

Laurent Dumartin

Tatjana Crnogorac-Jurcevic

Affiliations

Soon will be listed here.

Abstract

Anterior gradient 2, AGR2, is a small, 20 kDa protein that plays a vital role in oxidative protein folding in the endoplasmic reticulum. AGR2 is involved in several signal transduction pathways that are essential for cell survival. It was initially discovered in the African clawed frog, , where it plays an important function in embryonic development. Akin to several other developmental genes, it is also frequently deregulated in cancer, where it plays a decisive role in tumor initiation, progression and metastasis. In this review, we have summarized currently known AGR2 functions, its expression and function in embryonic and cancer development, as well as its potential as a candidate tumor biomarker and promising new target for cancer immunotherapy.

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