Pregnancy, Preeclampsia and Maternal Aging: From Epidemiology to Functional Genomics

Overview

Journal Ageing Res Rev

Specialty Geriatrics

Date 2021 Dec 6

PMID 34871806

Citations 14

Authors

Eliza C Miller

Ashley Wilczek

Natalie A Bello

Sarah Tom

Ronald Wapner

Yousin Suh

Affiliations

Soon will be listed here.

Abstract

Women live longer than men but experience greater disability and a longer period of illness as they age. Despite clear sex differences in aging, the impact of pregnancy and its complications, such as preeclampsia, on aging is an underexplored area of geroscience. This review summarizes our current knowledge about the complex links between pregnancy and age-related diseases, including evidence from epidemiology, clinical research, and genetics. We discuss the relationship between normal and pathological pregnancy and maternal aging, using preeclampsia as a primary example. We review the results of human genetics studies of preeclampsia, including genome wide association studies (GWAS), and attempted to catalog genes involved in preeclampsia as a gateway to mechanisms underlying an increased risk of later life cardio- and neuro- vascular events. Lastly, we discuss challenges in interpreting the GWAS of preeclampsia and provide a functional genomics framework for future research needed to fully realize the promise of GWAS in identifying targets for geroprotective prevention and therapeutics against preeclampsia.

Citing Articles

CITED2 is highly-expressed and PRX4 is poorly-expressed in preeclampsia and have diagnostic values.

Yang C, Song Z J Hum Hypertens. 2025; .

PMID: 40016392 DOI: 10.1038/s41371-025-00995-w.

Preeclampsia as a Study Model for Aging: The Klotho Gene Paradigm.

Cecati M, Fumarola S, Vaiasicca S, Cianfruglia L, Vignini A, Giannubilo S Int J Mol Sci. 2025; 26(3).

PMID: 39940672 PMC: 11817256. DOI: 10.3390/ijms26030902.

Investigating genetic links between biological aging and adverse pregnancy outcomes.

Sun N, Yang K, Wang H, Zhou W Biogerontology. 2025; 26(2):56.

PMID: 39920341 DOI: 10.1007/s10522-025-10198-y.

Placenta location, a prognostic determinant for the incidence of preeclampsia.

Alikhani F, Aalinezhad M, Bahrami M, Geravandi M BMC Pregnancy Childbirth. 2024; 24(1):835.

PMID: 39707286 PMC: 11660645. DOI: 10.1186/s12884-024-07050-5.

LINC01410 accelerates the invasion of trophoblast cells by modulating METTL3/Fas.

Yang Y, Chen M, Lan R, Gong H Mol Biol Rep. 2024; 51(1):895.

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