Hexarelin Modulates Lung Mechanics, Inflammation, and Fibrosis in Acute Lung Injury

Overview

Journal Drug Target Insights

Specialty Pharmacology

Date 2021 Dec 6

PMID 34871336

Citations 6

Authors

Vanessa Zambelli

Laura Rizzi

Paolo Delvecchio

Elena Bresciani

Emanuele Rezoagli

Laura Molteni

Ramona Meanti

Maria Serena Cuttin

Giorgio Bovo

Silvia Coco

Robert J Omeljaniuk

Vittorio Locatelli

Giacomo Bellani

Antonio Torsello

Affiliations

Soon will be listed here.

Citing Articles

Pharmacological targeting of the hyper-inflammatory response to SARS-CoV-2-infected K18-hACE2 mice using a cluster of differentiation 36 receptor modulator.

Gauvin J, Huynh D, Dubuc I, Le C, Tugores R, Flamand N Front Pharmacol. 2024; 15:1303342.

PMID: 38384295 PMC: 10879382. DOI: 10.3389/fphar.2024.1303342.

Growth hormone secretagogues modulate inflammation and fibrosis in mouse model of Duchenne muscular dystrophy.

Boccanegra B, Cappellari O, Mantuano P, Trisciuzzi D, Mele A, Tulimiero L Front Immunol. 2023; 14:1119888.

PMID: 37122711 PMC: 10130389. DOI: 10.3389/fimmu.2023.1119888.

Treatment with levosimendan in an experimental model of early ventilator-induced diaphragmatic dysfunction.

Zambelli V, Murphy E, Delvecchio P, Rizzi L, Fumagalli R, Rezoagli E Drug Target Insights. 2023; 17:39-44.

PMID: 37070031 PMC: 10105369. DOI: 10.33393/dti.2023.2574.

Protective Effects of Hexarelin and JMV2894 in a Human Neuroblastoma Cell Line Expressing the SOD1-G93A Mutated Protein.

Meanti R, Licata M, Rizzi L, Bresciani E, Molteni L, Coco S Int J Mol Sci. 2023; 24(2).

PMID: 36674509 PMC: 9863688. DOI: 10.3390/ijms24020993.

Potential Applications for Growth Hormone Secretagogues Treatment of Amyotrophic Lateral Sclerosis.

Meanti R, Bresciani E, Rizzi L, Coco S, Zambelli V, Dimitroulas A Curr Neuropharmacol. 2022; 21(12):2376-2394.

PMID: 36111771 PMC: 10616926. DOI: 10.2174/1570159X20666220915103613.

References

Amigoni M, Bellani G, Zambelli V, Scanziani M, Farina F, Fagnani L . Unilateral acid aspiration augments the effects of ventilator lung injury in the contralateral lung. Anesthesiology. 2013; 119(3):642-51. DOI: 10.1097/ALN.0b013e318297d487. View

Locatelli V, Rossoni G, Schweiger F, Torsello A, De Gennaro Colonna V, Bernareggi M . Growth hormone-independent cardioprotective effects of hexarelin in the rat. Endocrinology. 1999; 140(9):4024-31. DOI: 10.1210/endo.140.9.6948. View

Sibilia V, Torsello A, Pagani F, Rapetti D, Lattuada N, Locatelli V . Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat. Peptides. 2004; 25(12):2163-70. DOI: 10.1016/j.peptides.2004.08.001. View

Nagaya N, Miyatake K, Uematsu M, Oya H, Shimizu W, Hosoda H . Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure. J Clin Endocrinol Metab. 2001; 86(12):5854-9. DOI: 10.1210/jcem.86.12.8115. View

Ware L, Matthay M . The acute respiratory distress syndrome. N Engl J Med. 2000; 342(18):1334-49. DOI: 10.1056/NEJM200005043421806. View

Bresciani E, Pitsikas N, Tamiazzo L, Luoni M, Bulgarelli I, Cocchi D . Feeding behavior during long-term hexarelin administration in young and old rats. J Endocrinol Invest. 2008; 31(7):647-52. DOI: 10.1007/BF03345618. View

Tager A, Kradin R, LaCamera P, Bercury S, Campanella G, Leary C . Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10. Am J Respir Cell Mol Biol. 2004; 31(4):395-404. DOI: 10.1165/rcmb.2004-0175OC. View

Deng W, Deng Y, Deng J, Wang D, Zhang T . Losartan attenuated lipopolysaccharide-induced lung injury by suppression of lectin-like oxidized low-density lipoprotein receptor-1. Int J Clin Exp Pathol. 2016; 8(12):15670-6. PMC: 4730049. View

Conte E, Camerino G, Mele A, De Bellis M, Pierno S, Rana F . Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia. J Cachexia Sarcopenia Muscle. 2017; 8(3):386-404. PMC: 5703021. DOI: 10.1002/jcsm.12185. View

10.

Aggarwal N, King L, DAlessio F . Diverse macrophage populations mediate acute lung inflammation and resolution. Am J Physiol Lung Cell Mol Physiol. 2014; 306(8):L709-25. PMC: 3989724. DOI: 10.1152/ajplung.00341.2013. View

11.

Peiris J, Yuen K, Osterhaus A, Stohr K . The severe acute respiratory syndrome. N Engl J Med. 2003; 349(25):2431-41. DOI: 10.1056/NEJMra032498. View

12.

Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G . Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc Natl Acad Sci U S A. 1988; 85(24):9386-90. PMC: 282757. DOI: 10.1073/pnas.85.24.9386. View

13.

Katugampola S, Pallikaros Z, Davenport A . [125I-His(9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with athersclerosis. Br J Pharmacol. 2001; 134(1):143-9. PMC: 1572927. DOI: 10.1038/sj.bjp.0704228. View

14.

Kuba K, Imai Y, Ohto-Nakanishi T, Penninger J . Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacol Ther. 2010; 128(1):119-28. PMC: 7112678. DOI: 10.1016/j.pharmthera.2010.06.003. View

15.

Bulgarelli I, Tamiazzo L, Bresciani E, Rapetti D, Caporali S, Lattuada D . Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils. J Neurosci Res. 2009; 87(12):2718-27. DOI: 10.1002/jnr.22088. View

16.

Bachofen M, Weibel E . Structural alterations of lung parenchyma in the adult respiratory distress syndrome. Clin Chest Med. 1982; 3(1):35-56. View

17.

Torsello A, Bresciani E, Rossoni G, Avallone R, Tulipano G, Cocchi D . Ghrelin plays a minor role in the physiological control of cardiac function in the rat. Endocrinology. 2003; 144(5):1787-92. DOI: 10.1210/en.2002-221048. View

18.

Georgiadis D, Beau F, Czarny B, Cotton J, Yiotakis A, Dive V . Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors. Circ Res. 2003; 93(2):148-54. DOI: 10.1161/01.RES.0000081593.33848.FC. View

19.

Biagini G, Torsello A, Marinelli C, Gualtieri F, Vezzali R, Coco S . Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus. Eur J Pharmacol. 2011; 670(1):130-6. DOI: 10.1016/j.ejphar.2011.08.020. View

20.

Bellani G, Laffey J, Pham T, Fan E, Brochard L, Esteban A . Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA. 2016; 315(8):788-800. DOI: 10.1001/jama.2016.0291. View