Notoginseng Triterpenes Inhibited Autophagy in Random Flaps the Beclin-1/VPS34/LC3 Signaling Pathway to Improve Tissue Survival

Overview

Journal Front Bioeng Biotechnol

Date 2021 Dec 6

PMID 34869285

Citations 4

Authors

Zhiyang Huang

Xiaobin Luo

Yifan Zhang

Yibo Ying

Xiong Cai

Wenjie Lu

Juan Zhao

Yutian Wang

Wenwei Lin

Yurong Tu

Ziyue Xiang

Qiuji Wu

Shengwu Yang

Sipin Zhu

Xiaoyang Li

Affiliations

Soon will be listed here.

Abstract

Random flaps are widely used in tissue reconstruction, attributed to the lack of vascular axial limitation. Nevertheless, the distal end of the flap is prone to necrosis due to the lack of blood supply. Notoginseng triterpenes (NTs) are the active components extracted from , reducing oxygen consumption and improving the body's tolerance to hypoxia. However, their role in random flap survival has not been elucidated. In this study, we used a mouse random skin flap model to verify that NT can promote cell proliferation and migration and that increasing blood perfusion can effectively improve the survival area of a skin flap. Our study also showed that the autophagy of random flaps after NT treatment was activated through the Beclin-1/VPS34/LC3 signaling pathway, and the therapeutic effect of NT significantly decreased after VPS34 IN inhibited autophagy. In conclusion, we have demonstrated that NT can significantly improve the survival rate of random flaps through the Beclin-1/VPS34/LC3 signaling pathway, suggesting that it might be a promising clinical treatment option.

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