Role of the Extracellular Traps in Central Nervous System

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Dec 6

PMID 34868063

Citations 15

Authors

Xinyan Wu

Hanhai Zeng

Lingxin Cai

Gao Chen

Affiliations

Soon will be listed here.

Abstract

It has been reported that several immune cells can release chromatin and granular proteins into extracellular space in response to the stimulation, forming extracellular traps (ETs). The cells involved in the extracellular trap formation are recognized including neutropils, macrophages, basophils, eosinophils, and mast cells. With the development of research related to central nervous system, the role of ETs has been valued in neuroinflammation, blood-brain barrier, and other fields. Meanwhile, it has been found that microglial cells as the resident immune cells of the central nervous system can also release ETs, updating the original understanding. This review aims to clarify the role of the ETs in the central nervous system, especially in neuroinflammation and blood-brain barrier.

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