The Effect of a Multimodal Dementia Prevention Program Involving Community-dwelling Elderly

Overview

Journal Psychogeriatrics

Specialties Geriatrics
Psychology

Date 2021 Dec 6

PMID 34866286

Citations 2

Authors

Hiroyuki Kajita

Kiyoshi Maeda

Tohmi Osaki

Yasumasa Kakei

Kavita U Kothari

Yoji Nagai

Affiliations

Soon will be listed here.

Abstract

Background: With the rapid increase in the average age of society, the number of people with dementia has increased in Japan. Thus, the need to prevent dementia is greater, and prevention programs have been implemented throughout Japan. This study aims to evaluate both the short-term and the long-term effects of a dementia prevention program on physical and cognitive function in community-dwelling elderly.

Methods: Cognitive and physical assessments were carried out at baseline for a sample including 57 elderly participants. The participants underwent an intensive training program lasting for 2 h per week for 10 days. After the last period of training, the assessment performed was reapplied. The outcome measures used to establish effectiveness were a Mini-Mental State Examination, Five Cognitive Tests, a Cognitive Function Instrument, a Timed Up & Go Test, a grip strength evaluation, a Geriatric Depression Scale, an EQ-5D and a Physical Activity Scale for the Elderly. Participants were then divided randomly into two groups: a booster group and a non-booster group. The booster group received booster training every 3 months after the intensive training period, whereas the non-booster group did not. Both groups were monitored every 6 months for approximately two and a half years after baseline assessment.

Results: The Mini-Mental State Examination, the subtests of the Five Cognitive Tests (attention, memory, language and reasoning) and the Timed Up & Go Test revealed a significant improvement after intensive training. For most of the outcome measures, the booster training showed no additional significant improvements.

Conclusions: In this study, intensive training had a short-term positive effect. Although the effect of the booster training was not clear, the functions of the elderly participants were found to be maintained during a follow-up assessment. The study findings recommend conducting intensive training for the community-dwelling elderly without follow-up training.

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References

Hagiwara A, Ito N, Sawai K, Kazuma K . Validity and reliability of the Physical Activity Scale for the Elderly (PASE) in Japanese elderly people. Geriatr Gerontol Int. 2008; 8(3):143-51. DOI: 10.1111/j.1447-0594.2008.00463.x. View

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

Taniguchi Y, Shinkai S, Nishi M, Murayama H, Nofuji Y, Yoshida H . Nutritional biomarkers and subsequent cognitive decline among community-dwelling older Japanese: a prospective study. J Gerontol A Biol Sci Med Sci. 2014; 69(10):1276-83. DOI: 10.1093/gerona/glt286. View

Olazaran J, Reisberg B, Clare L, Cruz I, Pena-Casanova J, Del Ser T . Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord. 2010; 30(2):161-78. DOI: 10.1159/000316119. View

Arai H, Ouchi Y, Toba K, Endo T, Shimokado K, Tsubota K . Japan as the front-runner of super-aged societies: Perspectives from medicine and medical care in Japan. Geriatr Gerontol Int. 2015; 15(6):673-87. DOI: 10.1111/ggi.12450. View

Li C, Neugroschl J, Luo X, Zhu C, Aisen P, Ferris S . The Utility of the Cognitive Function Instrument (CFI) to Detect Cognitive Decline in Non-Demented Older Adults. J Alzheimers Dis. 2017; 60(2):427-437. PMC: 6417419. DOI: 10.3233/JAD-161294. View

Falck R, Davis J, Best J, Crockett R, Liu-Ambrose T . Impact of exercise training on physical and cognitive function among older adults: a systematic review and meta-analysis. Neurobiol Aging. 2019; 79:119-130. DOI: 10.1016/j.neurobiolaging.2019.03.007. View

Northey J, Cherbuin N, Pumpa K, Smee D, Rattray B . Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis. Br J Sports Med. 2017; 52(3):154-160. DOI: 10.1136/bjsports-2016-096587. View

. EuroQol--a new facility for the measurement of health-related quality of life. Health Policy. 1990; 16(3):199-208. DOI: 10.1016/0168-8510(90)90421-9. View

10.

Winslow B, Onysko M, Stob C, Hazlewood K . Treatment of Alzheimer disease. Am Fam Physician. 2011; 83(12):1403-12. View

11.

Hersi M, Irvine B, Gupta P, Gomes J, Birkett N, Krewski D . Risk factors associated with the onset and progression of Alzheimer's disease: A systematic review of the evidence. Neurotoxicology. 2017; 61:143-187. DOI: 10.1016/j.neuro.2017.03.006. View

12.

Nomura K, Karita K, Araki A, Nishioka E, Muto G, Iwai-Shimada M . For making a declaration of countermeasures against the falling birth rate from the Japanese Society for Hygiene: summary of discussion in the working group on academic research strategy against an aging society with low birth rate. Environ Health Prev Med. 2019; 24(1):14. PMC: 6402135. DOI: 10.1186/s12199-019-0768-x. View

13.

Arvanitakis Z, Shah R, Bennett D . Diagnosis and Management of Dementia: Review. JAMA. 2019; 322(16):1589-1599. PMC: 7462122. DOI: 10.1001/jama.2019.4782. View

14.

Anstey K, Low L . Normal cognitive changes in aging. Aust Fam Physician. 2004; 33(10):783-7. View

15.

Lazarov O, Robinson J, Tang Y, Hairston I, Korade-Mirnics Z, Lee V . Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell. 2005; 120(5):701-13. DOI: 10.1016/j.cell.2005.01.015. View

16.

Kojima S, Murotani K, Zhou B, Kothari K, Fukushima M, Nagai Y . Assessing long-term care risk in older individuals with possible cognitive decline: A large population-based study using the Kihon Checklist. Geriatr Gerontol Int. 2019; 19(7):598-603. DOI: 10.1111/ggi.13677. View

17.

Venturelli M, Scarsini R, Schena F . Six-month walking program changes cognitive and ADL performance in patients with Alzheimer. Am J Alzheimers Dis Other Demen. 2011; 26(5):381-8. PMC: 10845333. DOI: 10.1177/1533317511418956. View

18.

Fukutomi E, Okumiya K, Wada T, Sakamoto R, Ishimoto Y, Kimura Y . Importance of cognitive assessment as part of the "Kihon Checklist" developed by the Japanese Ministry of Health, Labor and Welfare for prediction of frailty at a 2-year follow up. Geriatr Gerontol Int. 2012; 13(3):654-62. DOI: 10.1111/j.1447-0594.2012.00959.x. View

19.

Podsiadlo D, Richardson S . The timed "Up & Go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991; 39(2):142-8. DOI: 10.1111/j.1532-5415.1991.tb01616.x. View

20.

Owen A, Hampshire A, Grahn J, Stenton R, Dajani S, Burns A . Putting brain training to the test. Nature. 2010; 465(7299):775-8. PMC: 2884087. DOI: 10.1038/nature09042. View