Daytime Eating Prevents Internal Circadian Misalignment and Glucose Intolerance in Night Work

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2021 Dec 3

PMID 34860550

Citations 41

Authors

Sarah L Chellappa

Jingyi Qian

Nina Vujovic

Christopher J Morris

Arlet Nedeltcheva

Hoa Nguyen

Nishath Rahman

Su Wei Heng

Lauren Kelly

Kayla Kerlin-Monteiro

Suhina Srivastav

Wei Wang

Daniel Aeschbach

Charles A Czeisler

Steven A Shea

Gail K Adler

Marta Garaulet

Frank A J L Scheer

Affiliations

Soon will be listed here.

Abstract

Night work increases diabetes risk. Misalignment between the central circadian “clock” and daily behaviors, typical in night workers, impairs glucose tolerance, likely due to internal misalignment between central and peripheral circadian rhythms. Whether appropriate circadian alignment of eating can prevent internal circadian misalignment and glucose intolerance is unknown. In a 14-day circadian paradigm, we assessed glycemic control during simulated night work with either nighttime or daytime eating. Assessment of central (body temperature) and peripheral (glucose and insulin) endogenous circadian rhythms happened during constant routine protocols before and after simulated night work. Nighttime eating led to misalignment between central and peripheral (glucose) endogenous circadian rhythms and impaired glucose tolerance, whereas restricting meals to daytime prevented it. These findings offer a behavioral approach to preventing glucose intolerance in shift workers.

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