Pediatric Multisystem Inflammatory Syndrome Temporally Associated with SARS-CoV-2 Symptoms in Iran

Overview

Journal Future Virol

Specialty Microbiology

Date 2021 Dec 3

PMID 34858514

Citations 1

Authors

Mehran Akbari

Mojtaba Didehdar

Mohsen Nazari

Davood Azadi

Affiliations

Soon will be listed here.

Abstract

We report two cases of pediatric patients diagnosed and treated for pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS) symptoms. Two previously healthy 3- and 4-year-old boys were referred to the hospital after 5 days of 39°C fever, with symptoms such as erythema multiform in the lower extremities, irritability, refusal to eat, restlessness, lymphadenopathy, conjunctivitis and abnormal echocardiography. After 8 days of hospitalization, the patients showed normal laboratory tests, improvement of clinical condition and were discharged from the hospital. This study raised several issues for physicians about SARS-CoV-2, its complications, diagnosis and treatment. Based on our results, pediatrics with PIMS-TS should be first screened for SARS-CoV-2, then treated with a combination of antivirals, anti-inflammatories, antibiotics and intravenous immune globulin.

Citing Articles

The Effect of Change Position on Cardiac Function Patterns on Patients with COVID-19 Diagnosis: A Clinical Trial Study.

Akbari M, Jafarimanesh H, Nasiri A, Rostami H, Mahdavi Z, Fayazi N Curr Health Sci J. 2024; 50(2):223-231.

PMID: 39371069 PMC: 11447492. DOI: 10.12865/CHSJ.50.02.07.

References

She J, Liu L, Liu W . COVID-19 epidemic: Disease characteristics in children. J Med Virol. 2020; 92(7):747-754. PMC: 7228385. DOI: 10.1002/jmv.25807. View

Geng Y, Wei Z, Qian H, Huang J, Lodato R, Castriotta R . Pathophysiological characteristics and therapeutic approaches for pulmonary injury and cardiovascular complications of coronavirus disease 2019. Cardiovasc Pathol. 2020; 47:107228. PMC: 7162778. DOI: 10.1016/j.carpath.2020.107228. View

Wevers B, van der Hoek L . Recently discovered human coronaviruses. Clin Lab Med. 2009; 29(4):715-24. PMC: 7131583. DOI: 10.1016/j.cll.2009.07.007. View

Toubiana J, Poirault C, Corsia A, Bajolle F, Fourgeaud J, Angoulvant F . Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020; 369:m2094. PMC: 7500538. DOI: 10.1136/bmj.m2094. View

Haslak F, Barut K, Durak C, Aliyeva A, Yildiz M, Guliyeva V . Clinical features and outcomes of 76 patients with COVID-19-related multi-system inflammatory syndrome in children. Clin Rheumatol. 2021; 40(10):4167-4178. PMC: 8178032. DOI: 10.1007/s10067-021-05780-x. View

Zhang R, Li Y, Zhang A, Wang Y, Molina M . Identifying airborne transmission as the dominant route for the spread of COVID-19. Proc Natl Acad Sci U S A. 2020; 117(26):14857-14863. PMC: 7334447. DOI: 10.1073/pnas.2009637117. View

Yeo W, Ng Q . Distinguishing between typical Kawasaki disease and multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2. Med Hypotheses. 2020; 144:110263. PMC: 7480253. DOI: 10.1016/j.mehy.2020.110263. View

Abdool Karim S, de Oliveira T . New SARS-CoV-2 Variants - Clinical, Public Health, and Vaccine Implications. N Engl J Med. 2021; 384(19):1866-1868. PMC: 8008749. DOI: 10.1056/NEJMc2100362. View

Rothan H, Byrareddy S . The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020; 109:102433. PMC: 7127067. DOI: 10.1016/j.jaut.2020.102433. View

10.

Ouldali N, Pouletty M, Mariani P, Beyler C, Blachier A, Bonacorsi S . Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis. Lancet Child Adolesc Health. 2020; 4(9):662-668. PMC: 7332278. DOI: 10.1016/S2352-4642(20)30175-9. View

11.

Rostad B, Shah J, Rostad C, Jaggi P, Richer E, Linam L . Chest radiograph features of multisystem inflammatory syndrome in children (MIS-C) compared to pediatric COVID-19. Pediatr Radiol. 2021; 51(2):231-238. PMC: 7785920. DOI: 10.1007/s00247-020-04921-9. View

12.

Ahmed M, Advani S, Moreira A, Zoretic S, Martinez J, Chorath K . Multisystem inflammatory syndrome in children: A systematic review. EClinicalMedicine. 2020; 26:100527. PMC: 7473262. DOI: 10.1016/j.eclinm.2020.100527. View

13.

Davies P, Evans C, Kanthimathinathan H, Lillie J, Brierley J, Waters G . Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study. Lancet Child Adolesc Health. 2020; 4(9):669-677. PMC: 7347350. DOI: 10.1016/S2352-4642(20)30215-7. View

14.

Tagarro A, Epalza C, Santos M, Sanz-Santaeufemia F, Otheo E, Moraleda C . Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children in Madrid, Spain. JAMA Pediatr. 2020; . PMC: 7142799. DOI: 10.1001/jamapediatrics.2020.1346. View

15.

Akbari M, Fayazi N, Kazemzadeh Y, Didehdar M, Momeni H, Abedi B . Evaluate the Case Fatality Rate (CFR) and Basic Reproductive Rate (R-naught) of COVID-19. Curr Health Sci J. 2021; 47(2):270-274. PMC: 8551904. DOI: 10.12865/CHSJ.47.02.18. View

16.

Akbari M, Kazemzadeh Y, Fayazi N, Sadeghi K, Orouji M, Momeni H . Investigation of the Epidemiological Situation and the Incidence of Covid 19 Disease in an Area of Markazi Province in Iran Country. Curr Health Sci J. 2021; 47(1):16-22. PMC: 8200612. DOI: 10.12865/CHSJ.47.01.03. View

17.

Sinha I, Harwood R, Semple M, Hawcutt D, Thursfield R, Narayan O . COVID-19 infection in children. Lancet Respir Med. 2020; 8(5):446-447. PMC: 7154504. DOI: 10.1016/S2213-2600(20)30152-1. View

18.

Rivera-Figueroa E, Santos R, Simpson S, Garg P . Incomplete Kawasaki Disease in a Child with Covid-19. Indian Pediatr. 2020; 57(7):680-681. PMC: 7387257. View