Pathogenesis of IgA Vasculitis: An Up-To-Date Review

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Dec 3

PMID 34858429

Citations 47

Authors

Yan Song

Xiaohan Huang

Guizhen Yu

Jianjun Qiao

Jun Cheng

Jianyong Wu

Jianghua Chen

Affiliations

Soon will be listed here.

Abstract

Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls. IgAV is the most common form of vasculitis in children; typical symptoms include palpable purpura, arthritis or arthralgia, abdominal pain, and hematuria or proteinuria. Galactose-deficient IgA1 is detected in the tissues of the kidney and skin in patients with IgAV; it forms immune complexes leading to subsequent immune reactions and injuries. This report provides the recent advances in the understanding of environmental factors, genetics, abnormal innate and acquired immunity, and the role of galactose-deficient IgA1 immunocomplexes in the pathogenesis of IgAV.

Citing Articles

Possible Threats of IgA Vasculitis in Children: One Center Experience.

Lanzbergaite-Manuilova E, Rusoniene S, Jankauskiene A Acta Med Litu. 2025; 31(2):254-263.

PMID: 40060258 PMC: 11887832. DOI: 10.15388/Amed.2024.31.2.4.

IgA nephropathy and IgA vasculitis in a pediatric Crohn's disease patient with early IgA deposition in vascular walls of intestines.

Tang J, Wang L, Zhou W, Mao Y, Zhang C, Shen J CEN Case Rep. 2025; .

PMID: 40011366 DOI: 10.1007/s13730-025-00970-x.

Tongue coating microbial communities vary in children with Henoch-Schönlein purpura.

Pang S, Yan Q, Lu Q, Chen W, Dai Y, Yue L Sci Rep. 2025; 15(1):5466.

PMID: 39953112 PMC: 11828920. DOI: 10.1038/s41598-025-88610-3.

IgA Vasculitis Presenting as Pulmonary-Renal Syndrome.

Bastos J, Medeiros J, Oliveira Silva C, Viana J, Marques S Cureus. 2025; 17(1):e77111.

PMID: 39925505 PMC: 11805601. DOI: 10.7759/cureus.77111.

The extent of intestinal involvement is closely related to the severity of IgAV: a risk stratification study based on CT.

Li Y, Xiong Z, Wang Y, Jiang Y, Shen Y, Hu X Ann Med. 2025; 57(1):2462260.

PMID: 39918160 PMC: 11809178. DOI: 10.1080/07853890.2025.2462260.

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