The Versatile Gasdermin Family: Their Function and Roles in Diseases

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Dec 3

PMID 34858408

Citations 61

Authors

Ju Zou

Yixiang Zheng

Yan Huang

Daolin Tang

Rui Kang

Ruochan Chen

Affiliations

Soon will be listed here.

Abstract

The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except for GSDMF). The GSDM-NT domain can be cleaved and released to form large oligomeric pores in the membrane that facilitate pyroptosis. The emerging roles of GSDMs include the regulation of various physiological and pathological processes, such as cell differentiation, coagulation, inflammation, and tumorigenesis. Here, we introduce the basic structure, activation, and expression patterns of GSDMs, summarize their biological and pathological functions, and explore their regulatory mechanisms in health and disease. This review provides a reference for the development of GSDM-targeted drugs to treat various inflammatory and tissue damage-related conditions.

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