Might Routine Vitamin A Monitoring in Cystic Fibrosis Patients Reduce Virus-Mediated Lung Pathology?

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Dec 3

PMID 34858393

Citations 3

Authors

Robert E Sealy

Sherri L Surman

Peter Vogel

Julia L Hurwitz

Affiliations

Soon will be listed here.

Abstract

Cystic fibrosis (CF) is an autosomal recessive gene disorder that affects tens of thousands of patients worldwide. Individuals with CF often succumb to progressive lung disease and respiratory failure following recurrent infections with bacteria. Viral infections can also damage the lungs and heighten the CF patient's susceptibility to bacterial infections and long-term sequelae. Vitamin A is a key nutrient important for immune health and epithelial cell integrity, but there is currently no consensus as to whether vitamin A should be monitored in CF patients. Here we evaluate previous literature and present results from a CF mouse model, showing that oral vitamin A supplements significantly reduce lung lesions that would otherwise persist for 5-6 weeks post-virus exposure. Based on these results, we encourage continued research and suggest that programs for the routine monitoring and regulation of vitamin A levels may help reduce virus-induced lung pathology in CF patients.

Citing Articles

Ocular Changes in Cystic Fibrosis: A Review.

Liberski S, Confalonieri F, Cofta S, Petrovski G, Kociecki J Int J Mol Sci. 2024; 25(12).

PMID: 38928397 PMC: 11203677. DOI: 10.3390/ijms25126692.

Retinol Binding Protein, Sunlight Hours, and the Influenza Virus-Specific Immune Response.

Patel N, Penkert R, Sealy R, Surman S, Jones B, Ringwald-Smith K Biomedicines. 2022; 10(9).

PMID: 36140423 PMC: 9496108. DOI: 10.3390/biomedicines10092322.

Hypothesis: Low Vitamin A and D Levels Worsen Clinical Outcomes When Children with Sickle Cell Disease Encounter Parvovirus B19.

Penkert R, Azul M, Sealy R, Jones B, Dowdy J, Hayden R Nutrients. 2022; 14(16).

PMID: 36014920 PMC: 9414848. DOI: 10.3390/nu14163415.

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