The Etiology of Auditory Hallucinations in Schizophrenia: From Multidimensional Levels

Overview

Journal Front Neurosci

Date 2021 Dec 3

PMID 34858129

Citations 4

Authors

Xu Shao

Yanhui Liao

Lin Gu

Wei Chen

Jinsong Tang

Affiliations

Soon will be listed here.

Abstract

Enormous efforts have been made to unveil the etiology of auditory hallucinations (AHs), and multiple genetic and neural factors have already been shown to have their own roles. Previous studies have shown that AHs in schizophrenia vary from those in other disorders, suggesting that they have unique features and possibly distinguishable mechanisms worthy of further investigation. In this review, we intend to offer a comprehensive summary of current findings related to AHs in schizophrenia from aspects of genetics and transcriptome, neurophysiology (neurometabolic and electroencephalogram studies), and neuroimaging (structural and functional magnetic resonance imaging studies and transcriptome-neuroimaging association study). Main findings include gene polymorphisms, glutamate level change, electroencephalographic alterations, and abnormalities of white matter fasciculi, cortical structure, and cerebral activities, especially in multiple regions, including auditory and language networks. More solid and comparable research is needed to replicate and integrate ongoing findings from multidimensional levels.

Citing Articles

Current Auditory Hallucinations Are Not Associated With Specific White Matter Diffusion Alterations in Schizophrenia.

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Imaging Transcriptomics of the Brain for Schizophrenia.

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Third-generation genome sequencing implicates medium-sized structural variants in chronic schizophrenia.

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Language abnormalities in schizophrenia: binding core symptoms through contemporary empirical evidence.

Chang X, Zhao W, Kang J, Xiang S, Xie C, Corona-Hernandez H Schizophrenia (Heidelb). 2022; 8(1):95.

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