E. Coli Nissle 1917 Modulates Host Glucose Metabolism Without Directly Acting on Glucose

Overview

Journal Sci Rep

Specialty Science

Date 2021 Dec 2

PMID 34853343

Citations 4

Authors

Theodore A Chavkin

Loc-Duyen Pham

Aleksandar Kostic

Affiliations

Soon will be listed here.

Abstract

Managing postprandial glycemic response, or the increase in blood sugar following a meal, is a crucial component to maintaining healthy blood sugar in patients with diabetes. To test whether oral probiotics can impact postprandial glycemic response, E. coli Nissle 1917 (EcN) was evaluated in an oral glucose tolerance test. Oral gavage of EcN concurrent with a glucose bolus reduced the post-gavage glycemic response in mice. However, there was no difference in glycemic response when comparing EcN to a mutant deficient in glucose metabolism. This suggests that while EcN can alter glycemic response to a glucose bolus, this effect is not mediated by direct uptake of glucose. Of the possible indirect effects EcN could have, gastric emptying rate was highlighted as a likely cause, but EcN had no effect on gastric emptying rate in mice. This leaves many more possible indirect explanations for the interaction between EcN and host glucose metabolism to be explored in future work.

Citing Articles

Administration of a Next-Generation Probiotic Nissle 1917-GLP-1 Alleviates Diabetes in Mice With Type 1 and Type 2 Diabetes.

Luo J, Fang Y, Qi Z, Cui F, Hu H, Li S Can J Infect Dis Med Microbiol. 2025; 2025:6675676.

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Modulation of gut microbiome in response to the combination of Nissle 1917 and sugars: a pilot study using host-free system reflecting impact on interpersonal microbiome.

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