Initial Evidence That Blockade of the CD40/CD154 Costimulation Pathway Alone is Sufficient As Maintenance Therapy in Xenotransplantation

Overview

Journal Xenotransplantation

Specialty General Surgery

Date 2021 Dec 1

PMID 34850468

Citations 10

Authors

David K C Cooper

Jeremy B Foote

Mariyam Javed

Huy Q Nguyen

Mohamed H Bikhet

Christophe Hansen-Estruch

David Ayares

Hidetaka Hara

Affiliations

Soon will be listed here.

Citing Articles

Cytotoxic Responses Mediated by NK Cells and Cytotoxic T Lymphocytes in Xenotransplantation.

Galdina V, Puga Yung G, Seebach J Transpl Int. 2025; 38:13867.

PMID: 40012743 PMC: 11862997. DOI: 10.3389/ti.2025.13867.

Surveillance and prevention of infection in clinical xenotransplantation.

Stewart A, Fishman J Clin Microbiol Rev. 2025; 38(1):e0015023.

PMID: 39887237 PMC: 11905366. DOI: 10.1128/cmr.00150-23.

The Evolution of Immunosuppressive Therapy in Pig-to-Nonhuman Primate Organ Transplantation.

Sanatkar S, Kinoshita K, Maenaka A, Hara H, Cooper D Transpl Int. 2025; 37:13942.

PMID: 39872238 PMC: 11770881. DOI: 10.3389/ti.2024.13942.

Developments in kidney xenotransplantation.

Xu H, He X Front Immunol. 2024; 14:1242478.

PMID: 38274798 PMC: 10808336. DOI: 10.3389/fimmu.2023.1242478.

Assessment of glomerular filtration and tubular secretion in baboons with life-supporting pig kidney grafts.

Hansen-Estruch C, Bikhet M, Shaik I, Vasudevan V, Zhao W, Javed M Xenotransplantation. 2023; 30(2):e12795.

PMID: 36820525 PMC: 10354795. DOI: 10.1111/xen.12795.

References

Shin J, Kim J, Kim J, Min B, Kim Y, Kim H . Long-term control of diabetes in immunosuppressed nonhuman primates (NHP) by the transplantation of adult porcine islets. Am J Transplant. 2015; 15(11):2837-50. DOI: 10.1111/ajt.13345. View

Shin J, Kim J, Min B, Yoon I, Kim H, Kim J . Pre-clinical results in pig-to-non-human primate islet xenotransplantation using anti-CD40 antibody (2C10R4)-based immunosuppression. Xenotransplantation. 2017; 25(1). PMC: 5809197. DOI: 10.1111/xen.12356. View

Yamamoto T, Hara H, Foote J, Wang L, Li Q, Klein E . Life-supporting Kidney Xenotransplantation From Genetically Engineered Pigs in Baboons: A Comparison of Two Immunosuppressive Regimens. Transplantation. 2019; 103(10):2090-2104. DOI: 10.1097/TP.0000000000002796. View

Iwase H, Yamamoto T, Cooper D . Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance?. Xenotransplantation. 2018; 26(2):e12472. PMC: 6476652. DOI: 10.1111/xen.12472. View

Bikhet M, Iwase H, Yamamoto T, Jagdale A, Foote J, Ezzelarab M . What Therapeutic Regimen Will Be Optimal for Initial Clinical Trials of Pig Organ Transplantation?. Transplantation. 2021; 105(6):1143-1155. DOI: 10.1097/TP.0000000000003622. View