The Use of Finite Mixture Models to Examine the Serum 25(OH)D Levels Among Saudis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2021 Nov 30

PMID 34847185

Authors

Ibrahim Al-Sumaih

Michael Donnelly

Ciaran ONeill

Affiliations

Soon will be listed here.

Abstract

Background: Recorded serum 25(OH)D in survey data varies with observed and unobserved respondent characteristics. The aim of this study was to expose latent population sub-groups and examine variation across groups regarding relationships between serum 25(OH)D and observable characteristics.

Methods: This study explored the role of unobserved heterogeneity on associations between surveyed 25(OH)D and various factors using a sample (n = 2,641) extracted from the Saudi Health Interview Survey (2013). Linear regression and finite mixture models (FMM) were estimated and compared. The number of latent classes in the FMM was chosen based on BIC score.

Result: Three latent classes were identified. Class I (39.82%), class II (41.03%), and class III (19.15%) with mean 25(OH)D levels of 22.79, 34.88, and 57.45 ng/ml respectively. Distinct patterns of associations with nutrition, behaviour and socio-demographic variables were recorded across classes that were not revealed in pooled linear regression.

Conclusion: FMM has the potential to provide additional insights on the relationship between 25(OH)D levels and observable characteristics. It should be more widely considered as a method of investigation in this area.

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