L-Menthol Increases Extracellular Dopamine and C-Fos-like Immunoreactivity in the Dorsal Striatum, and Promotes Ambulatory Activity in Mice

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2021 Nov 30

PMID 34847183

Citations 2

Authors

Toyoshi Umezu

Tomoharu Sano

Junko Hayashi

Affiliations

Soon will be listed here.

Abstract

Similar to psychostimulants, the peripheral administration of menthol promotes mouse motor activity, and the neurotransmitter dopamine has been suggested to be involved in this effect. The present study aimed to elucidate the effects of l-menthol on parts of the central nervous system that are involved in motor effects. The subcutaneous administration of l-menthol significantly increased the number of c-Fos-like immunoreactive nuclei in the dorsal striatum of the mice, and motor activity was promoted. It also increased the extracellular dopamine level in the dorsal striatum of the mice. These observations indicated that after subcutaneous administration, l-menthol enhances dopamine-mediated neurotransmission, and activates neuronal activity in the dorsal striatum, thereby promoting motor activity in mice.

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Expression of Concern: l-Menthol increases extracellular dopamine and c-Fos-like immunoreactivity in the dorsal striatum, and promotes ambulatory activity in mice.

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