Identification of Oligosaccharyltransferase As a Host Target for Inhibition of SARS-CoV-2 and Its Variants

Overview

Journal Cell Discov

Date 2021 Nov 30

PMID 34845185

Citations 8

Authors

Yi-Jiao Huang

Hui Zhao

Xun Huang

Yong-Qiang Deng

Xiao-Feng Li

Qing Ye

Rui-Ting Li

Yan-Peng Xu

Tian-Shu Cao

Cheng-Feng Qin

Affiliations

Soon will be listed here.

Citing Articles

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Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesis.

Si F, Song S, Yu R, Li Z, Wei W, Wu C iScience. 2023; 26(4):106280.

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Quantitative proteomics and biological activity of extracellular vesicles engineered to express SARS-CoV-2 spike protein.

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Regulation of angiotensin-converting enzyme 2 isoforms by type 2 inflammation and viral infection in human airway epithelium.

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Involvement of sialoglycans in SARS-COV-2 infection: Opportunities and challenges for glyco-based inhibitors.

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References

Wang G, Yang M, Duan Z, Liu F, Jin L, Long C . Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models. Cell Res. 2020; 31(1):17-24. PMC: 7705431. DOI: 10.1038/s41422-020-00450-0. View

Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M . Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020; 30(3):269-271. PMC: 7054408. DOI: 10.1038/s41422-020-0282-0. View

Tian W, Li D, Zhang N, Bai G, Yuan K, Xiao H . O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an "O-Follow-N" rule. Cell Res. 2021; 31(10):1123-1125. PMC: 8326647. DOI: 10.1038/s41422-021-00545-2. View

Zu S, Deng Y, Zhou C, Li J, Li L, Chen Q . 25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor. Cell Res. 2020; 30(11):1043-1045. PMC: 7431750. DOI: 10.1038/s41422-020-00398-1. View

Bhat E, Khan J, Sajjad N, Ali A, Aldakeel F, Mateen A . SARS-CoV-2: Insight in genome structure, pathogenesis and viral receptor binding analysis - An updated review. Int Immunopharmacol. 2021; 95:107493. PMC: 7904465. DOI: 10.1016/j.intimp.2021.107493. View

Yao H, Song Y, Chen Y, Wu N, Xu J, Sun C . Molecular Architecture of the SARS-CoV-2 Virus. Cell. 2020; 183(3):730-738.e13. PMC: 7474903. DOI: 10.1016/j.cell.2020.09.018. View

Prussia A, Thepchatri P, Snyder J, Plemper R . Systematic approaches towards the development of host-directed antiviral therapeutics. Int J Mol Sci. 2011; 12(6):4027-52. PMC: 3131607. DOI: 10.3390/ijms12064027. View

Cava C, Bertoli G, Castiglioni I . A protein interaction map identifies existing drugs targeting SARS-CoV-2. BMC Pharmacol Toxicol. 2020; 21(1):65. PMC: 7470683. DOI: 10.1186/s40360-020-00444-z. View

Shrimal S, Gilmore R . Oligosaccharyltransferase structures provide novel insight into the mechanism of asparagine-linked glycosylation in prokaryotic and eukaryotic cells. Glycobiology. 2018; 29(4):288-297. PMC: 6499010. DOI: 10.1093/glycob/cwy093. View

10.

Gordon D, Jang G, Bouhaddou M, Xu J, Obernier K, White K . A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020; 583(7816):459-468. PMC: 7431030. DOI: 10.1038/s41586-020-2286-9. View

11.

Puschnik A, Marceau C, Ooi Y, Majzoub K, Rinis N, Contessa J . A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity. Cell Rep. 2017; 21(11):3032-3039. PMC: 5734657. DOI: 10.1016/j.celrep.2017.11.054. View

12.

Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P . Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. Cell Host Microbe. 2020; 27(3):325-328. PMC: 7154514. DOI: 10.1016/j.chom.2020.02.001. View

13.

Plante J, Mitchell B, Plante K, Debbink K, Weaver S, Menachery V . The variant gambit: COVID-19's next move. Cell Host Microbe. 2021; 29(4):508-515. PMC: 7919536. DOI: 10.1016/j.chom.2021.02.020. View

14.

Oostra M, de Haan C, de Groot R, Rottier P . Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M. J Virol. 2006; 80(5):2326-36. PMC: 1395384. DOI: 10.1128/JVI.80.5.2326-2336.2006. View