Component Resolved Diagnosis and Risk Assessment in Food Allergy

Overview

Journal Acta Biomed

Specialty General Medicine

Date 2021 Nov 29

PMID 34842587

Citations 4

Authors

Alberto Martelli

Mauro Calvani

Thomas Foiadelli

Mariangela Tosca

Giuseppe Pingitore

Amelia Licari

Alessia Marseglia

Giorgio Ciprandi

Carlo Caffarelli

Affiliations

Soon will be listed here.

Abstract

Allergy testing should only be performed in the context of the clinical history as history provides the cornerstone of diagnosis. In food allergy, some allergy tests often give rise to false positive results and thus can lead to unnecessary avoidance or delay on foods introduction. The use of Component Resolved Diagnosis in combination with conventional sensitization testing improves analytical and diagnostic performance and can lead to the reduction of diagnostic oral food challenges. Component Resolved Diagnosis can be helpful in identifying some risks for the allergic child. Molecular diagnosis can help also in predicting the development of the allergy march, in severe reactions (lipid transfer protein, seed storage proteins, etc.) in food allergy and for potential clinical cross-reactivity.

Citing Articles

Amino Acid Profiling Identifies Disease-Specific Signatures in IgE-Mediated and Non-IgE-Mediated Food Allergy in Pediatric Patients with Atopic Dermatitis.

Packi K, Matysiak J, Plewa S, Klupczynska-Gabryszak A, Matuszewska E, Rzetecka N Biomedicines. 2023; 11(7).

PMID: 37509558 PMC: 10377369. DOI: 10.3390/biomedicines11071919.

Sensitization to nsLTP: A Retrospective Study in An Italian Pediatric Population over the Last Decade.

Indolfi C, Dinardo G, Klain A, Contieri M, Umano G, Decimo F J Immunol Res. 2023; 2023:4053799.

PMID: 37228443 PMC: 10205406. DOI: 10.1155/2023/4053799.

The Precision Allergy Molecular Diagnosis (PAMD@) in Monitoring the Atopic March in a Child with a Primary Food Allergy: Case Report.

Knyziak-Medrzycka I, Szychta M, Majsiak E, Fal A, Doniec Z, Cukrowska B J Asthma Allergy. 2022; 15:1263-1267.

PMID: 36105123 PMC: 9464625. DOI: 10.2147/JAA.S372928.

Analysis of the Serum Profile of Cytokines Involved in the T-Helper Cell Type 17 Immune Response Pathway in Atopic Children with Food Allergy.

Packi K, Matysiak J, Klimczak S, Matuszewska E, Breborowicz A, Pietkiewicz D Int J Environ Res Public Health. 2022; 19(13).

PMID: 35805534 PMC: 9265836. DOI: 10.3390/ijerph19137877.

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