15-Lipoxygenase and Its Metabolites in the Pathogenesis of Breast Cancer: A Double-edged Sword

Overview

Journal Lipids Health Dis

Publisher Biomed Central

Specialties Biochemistry
Endocrinology

Date 2021 Nov 28

PMID 34838055

Citations 11

Authors

Mohammad Amin Vaezi

Banafsheh Safizadeh

Amir Reza Eghtedari

Seyedeh Sara Ghorbanhosseini

Mostafa Rastegar

Vahid Salimi

Masoumeh Tavakoli-Yaraki

Affiliations

Soon will be listed here.

Abstract

15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been proposed recently as a new molecular target for regulating cancer cell growth. Aberrant expression of 15-lipoxygenase enzyme seems to play an indicative role in the pathology of different cancer types, tumor progression, metastasis, or apoptosis. Based on the fact that breast cancer is one of the most common cancers that imposes a burden of mortality in women also, on the other hand, evidence in experimental models and human studies indicate the emerging role of the 15-lipoxygenase pathway in breast cancer pathogenesis, we present a review of recent findings related to the role of 15- lipoxygenase enzyme and metabolites in breast cancer growth, apoptosis, metastasis, and invasion as well as their local and circulating expression pattern in patients with breast cancer. Our review supports the emerging role of 15- lipoxygenase in molecular and cellular processes regulating breast tumor cell fate with both positive and negative effects.

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