Advances in Glioma-associated Oncogene (GLI) Inhibitors for Cancer Therapy

Overview

Journal Invest New Drugs

Publisher Springer

Specialty Oncology

Date 2021 Nov 27

PMID 34837604

Citations 5

Authors

Meng Zhang

Lijuan Gao

Yiping Ye

Xiaoyu Li

Affiliations

Soon will be listed here.

Abstract

The Hedgehog/Glioma-associated oncogene homolog (HH/GLI) signaling pathway regulates self-renewal of rare and highly malignant cancer stem cells, which have been shown to account for the initiation and maintenance of tumor growth as well as for drug resistance, metastatic spread and relapse. As an important component of the Hh signaling pathway, glioma-associated oncogene (GLI) acts as a key signal transmission hub for various signaling pathways in many tumors. Here, we review direct and indirect inhibitors of GLI; summarize the abundant active structurally diverse natural GLI inhibitors; and discuss how to better develop and utilize GLI inhibitors to solve the problem of drug resistance in tumors of interest. In summary, GLI inhibitors will be promising candidates for various cancer treatments.

Citing Articles

Physiological analysis of the mechanism of Ci transcription factor activation through multiple Fused phosphorylation sites in Hedgehog signal transduction.

Kim H, Little J, Li J, Patel B, Kalderon D bioRxiv. 2025; .

PMID: 39896583 PMC: 11785250. DOI: 10.1101/2025.01.24.634727.

Molecular and clonal evolution reveal a common pathway of distant relapse gliomas.

Liu G, Bu C, Guo G, Zhang Z, Sheng Z, Deng K iScience. 2023; 26(9):107528.

PMID: 37649695 PMC: 10462858. DOI: 10.1016/j.isci.2023.107528.

Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies.

Jing J, Wu Z, Wang J, Luo G, Lin H, Fan Y Signal Transduct Target Ther. 2023; 8(1):315.

PMID: 37596267 PMC: 10439210. DOI: 10.1038/s41392-023-01559-5.

The emerging roles of Hedgehog signaling in tumor immune microenvironment.

Wang J, Cui B, Li X, Zhao X, Huang T, Ding X Front Oncol. 2023; 13:1171418.

PMID: 37213270 PMC: 10196179. DOI: 10.3389/fonc.2023.1171418.

From mesenchymal niches to engineered model systems: Exploring and exploiting biomechanical regulation of vertebrate hedgehog signalling.

Ghuloum F, Johnson C, Riobo-Del Galdo N, Amer M Mater Today Bio. 2022; 17:100502.

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