Rosai-Dorfman Disease.

Overview

Journal Pathologica

Specialty Pathology

Date 2021 Nov 27

PMID 34837097

Citations 3

Authors

Claudio Doglioni

Affiliations

Soon will be listed here.

Abstract

Rosai-Dorfman disease (RDD) is a rare form of non-Langerhans cell histiocytosis described by Rosai and Dorfman in 1969. It is a fascinating disease characterized by accumulation of large, pale histiocytes, frequently showing the emperipolesis phenomenon. The variety of pathological aspects and the spectrum of different clinical forms were deeply investigated by Prof. Rosai. Despite recent advancements in the dissection of pathogenetic mechanisms of RDD, with the identification of gene mutations in the MAP kinase pathway, several biological and clinical aspects of this disease remains to be elucidated: this is one of the Prof. Rosai's legacies.

Citing Articles

Case Report: Coexistence of Rosai-Dorfman disease and B-cell acute lymphoblastic leukemia in an adolescent.

Jenabzadeh A, Binesh F, Shahbaz A, Alavi S Front Pediatr. 2025; 13:1529833.

PMID: 40079030 PMC: 11897000. DOI: 10.3389/fped.2025.1529833.

Four cases of cutaneous Rosai-Dorfman in Black patients: A review of a single institution's experience with this rare disease.

Banbury S, Chu B, Hedberg M, Ogunleye T, Kim E, Rosenbach M JAAD Case Rep. 2023; 42:117-121.

PMID: 38090658 PMC: 10711361. DOI: 10.1016/j.jdcr.2023.09.032.

Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease.

Almasi S, Pancsa T, Tiszlavicz L, Sejben A CNS Oncol. 2023; 12(4):CNS103.

PMID: 37551608 PMC: 10701702. DOI: 10.2217/cns-2023-0006.

Synchronous Mediastinal and Central Nervous System Involvement in Rosai-Dorfman Disease: A Case Report.

Soto-Davila C, Klapper R, Afude J, Sangster G, Previgliano C Cureus. 2023; 15(6):e39984.

PMID: 37416014 PMC: 10321357. DOI: 10.7759/cureus.39984.

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