In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders-Systematic Review and Meta-Analysis

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2021 Nov 27

PMID 34831531

Citations 11

Authors

Marta Mazur

Artnora Ndokaj

Divyambika Catakapatri Venugopal

Michela Roberto

Cristina Albu

Maciej Jedlinski

Silverio Tomao

Iole Vozza

Grzegorz Trybek

Livia Ottolenghi

Fabrizio Guerra

Affiliations

Soon will be listed here.

Abstract

Objectives: Oral potentially malignant disorders (OPMDs) are lesions that may undergo malignant transformation to oral cancer. The early diagnosis and surveillance of OPMDs reduce the morbidity and mortality of patients. Diagnostic techniques based on medical images analysis have been developed to diagnose clinical conditions. This systematic review and meta-analysis aimed to evaluate the efficacy of imaging-based techniques compared to the gold standard of histopathology to assess their ability to correctly identify the presence of OPMDs.

Design: Literature searches of free text and MeSH terms were performed using MedLine (PubMed), Scopus, Google Scholar, and the Cochrane Library (from 2000 to 30 June 2020). The keywords used in the search strategy were: ("oral screening devices" or "autofluorescence" or "chemiluminescence" or "optical imaging" or "imaging technique") and ("oral dysplasia" or "oral malignant lesions" or "oral precancerosis").

Results: The search strategy identified 1282 potential articles. After analyzing the results and applying the eligibility criteria, the remaining 43 papers were included in the qualitative synthesis, and 34 of these were included in the meta-analysis.

Conclusions: None of the analyzed techniques based on assessing oral images can replace the biopsy. Further studies are needed to explore the role of techniques-based imaging analysis to identify an early noninvasive screening method.

Citing Articles

The Diagnostic Potential of Non-Invasive Tools for Oral Cancer and Precancer: A Systematic Review.

Pierfelice T, DAmico E, Cinquini C, Iezzi G, DArcangelo C, DErcole S Diagnostics (Basel). 2024; 14(18).

PMID: 39335712 PMC: 11431589. DOI: 10.3390/diagnostics14182033.

Optical imaging for screening and early cancer diagnosis in low-resource settings.

Richards-Kortum R, Lorenzoni C, Bagnato V, Schmeler K Nat Rev Bioeng. 2024; 2(1):25-43.

PMID: 39301200 PMC: 11412616. DOI: 10.1038/s44222-023-00135-4.

Salivary Histamine Levels in Patients with Oral Lichen Planus Lesions.

Radwan-Oczko M, Rybinska A, Mierzwicka A, Dus-Ilnicka I Medicina (Kaunas). 2024; 60(7).

PMID: 39064467 PMC: 11278918. DOI: 10.3390/medicina60071038.

Advancements in diagnosing oral potentially malignant disorders: leveraging Vision transformers for multi-class detection.

Vinayahalingam S, Van Nistelrooij N, Rothweiler R, Tel A, Verhoeven T, Troltzsch D Clin Oral Investig. 2024; 28(7):364.

PMID: 38849649 PMC: 11161543. DOI: 10.1007/s00784-024-05762-8.

Hyperspectral retinal imaging biomarkers of ocular and systemic diseases.

Saeed A, Hadoux X, van Wijngaarden P Eye (Lond). 2024; 39(4):667-672.

PMID: 38778136 PMC: 11885810. DOI: 10.1038/s41433-024-03135-9.

References

Schwarz R, Gao W, Weber C, Kurachi C, Lee J, El-Naggar A . Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy. Cancer. 2009; 115(8):1669-79. PMC: 2728679. DOI: 10.1002/cncr.24177. View

McGee S, Mardirossian V, Elackattu A, Mirkovic J, Pistey R, Gallagher G . Anatomy-based algorithms for detecting oral cancer using reflectance and fluorescence spectroscopy. Ann Otol Rhinol Laryngol. 2009; 118(11):817-26. PMC: 2860948. View

Borse V, Konwar A, Buragohain P . Oral cancer diagnosis and perspectives in India. Sens Int. 2021; 1:100046. PMC: 7515567. DOI: 10.1016/j.sintl.2020.100046. View

Wright J, Vered M . Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors. Head Neck Pathol. 2017; 11(1):68-77. PMC: 5340735. DOI: 10.1007/s12105-017-0794-1. View

Petruzzi M, Lucchese A, Nardi G, Lauritano D, Favia G, Serpico R . Evaluation of autofluorescence and toluidine blue in the differentiation of oral dysplastic and neoplastic lesions from non dysplastic and neoplastic lesions: a cross-sectional study. J Biomed Opt. 2014; 19(7):76003. DOI: 10.1117/1.JBO.19.7.076003. View

Amirchaghmaghi M, Mohtasham N, Delavarian Z, Shakeri M, Hatami M, Mosannen Mozafari P . The diagnostic value of the native fluorescence visualization device for early detection of premalignant/malignant lesions of the oral cavity. Photodiagnosis Photodyn Ther. 2017; 21:19-27. DOI: 10.1016/j.pdpdt.2017.10.019. View

Yang E, Schwarz R, Lang A, Bass N, Badaoui H, Vohra I . Multimodal Optical Imaging: Improved Detection of Oral Dysplasia in Low-Risk Oral Mucosal Lesions. Cancer Prev Res (Phila). 2018; 11(8):465-476. PMC: 6082417. DOI: 10.1158/1940-6207.CAPR-18-0032. View

Yang E, Vohra I, Badaoui H, Schwarz R, Cherry K, Jacob J . Prospective evaluation of oral premalignant lesions using a multimodal imaging system: a pilot study. Head Neck. 2019; 42(2):171-179. PMC: 7003735. DOI: 10.1002/hed.25978. View

Li Y, Lu R, Zhang J, Zhou G . Inter-and intra-observer agreement on the judgment of toluidine blue staining for screening of oral potentially malignant disorders and oral cancer. Clin Oral Investig. 2018; 23(4):1709-1714. DOI: 10.1007/s00784-018-2595-7. View

10.

Pierce M, Schwarz R, Bhattar V, Mondrik S, Williams M, Lee J . Accuracy of in vivo multimodal optical imaging for detection of oral neoplasia. Cancer Prev Res (Phila). 2012; 5(6):801-9. PMC: 3560936. DOI: 10.1158/1940-6207.CAPR-11-0555. View

11.

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

12.

Gulshan V, Peng L, Coram M, Stumpe M, Wu D, Narayanaswamy A . Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs. JAMA. 2016; 316(22):2402-2410. DOI: 10.1001/jama.2016.17216. View

13.

Lane P, Gilhuly T, Whitehead P, Zeng H, Poh C, Ng S . Simple device for the direct visualization of oral-cavity tissue fluorescence. J Biomed Opt. 2006; 11(2):024006. DOI: 10.1117/1.2193157. View

14.

Chiang T, Lin Y, Li Y, Wu C, Kuo C, Chen Y . Comparative evaluation of autofluorescence imaging and histopathological investigation for oral potentially malignant disorders in Taiwan. Clin Oral Investig. 2018; 23(5):2395-2402. DOI: 10.1007/s00784-018-2691-8. View

15.

Hassan C, Wallace M, Sharma P, Maselli R, Craviotto V, Spadaccini M . New artificial intelligence system: first validation study versus experienced endoscopists for colorectal polyp detection. Gut. 2019; 69(5):799-800. DOI: 10.1136/gutjnl-2019-319914. View

16.

Mehrotra R, Singh M, Thomas S, Nair P, Pandya S, Nigam N . A cross-sectional study evaluating chemiluminescence and autofluorescence in the detection of clinically innocuous precancerous and cancerous oral lesions. J Am Dent Assoc. 2010; 141(2):151-6. DOI: 10.14219/jada.archive.2010.0132. View

17.

Yang S, Lee Y, Chang L, Hwang C, Chen T . Diagnostic significance of narrow-band imaging for detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral leukoplakia. Laryngoscope. 2012; 122(12):2754-61. DOI: 10.1002/lary.23629. View

18.

Jayanthi J, Nisha G, Manju S, Philip E, Jeemon P, Baiju K . Diffuse reflectance spectroscopy: diagnostic accuracy of a non-invasive screening technique for early detection of malignant changes in the oral cavity. BMJ Open. 2011; 1(1):e000071. PMC: 3191415. DOI: 10.1136/bmjopen-2011-000071. View

19.

Sharwani A, Jerjes W, Salih V, MacRobert A, El-Maaytah M, Khalil H . Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in detecting oral premalignancy. J Photochem Photobiol B. 2006; 83(1):27-33. DOI: 10.1016/j.jphotobiol.2005.11.007. View

20.

Warnakulasuriya S, Johnson N, van der Waal I . Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007; 36(10):575-80. DOI: 10.1111/j.1600-0714.2007.00582.x. View