Cell Cycle, Telomeres, and Telomerase in Spp.: What Do We Know So Far?

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2021 Nov 27

PMID 34831418

Citations 2

Authors

Luiz H C Assis

Debora Andrade-Silva

Mark E Shiburah

Beatriz C D de Oliveira

Stephany C Paiva

Bryan E Abuchery

Yete G Ferri

Veronica S Fontes

Leilane S de Oliveira

Marcelo S da Silva

Maria Isabel N Cano

Affiliations

Soon will be listed here.

Abstract

Leishmaniases belong to the inglorious group of neglected tropical diseases, presenting different degrees of manifestations severity. It is caused by the transmission of more than 20 species of parasites of the genus. Nevertheless, the disease remains on the priority list for developing new treatments, since it affects millions in a vast geographical area, especially low-income people. Molecular biology studies are pioneers in parasitic research with the aim of discovering potential targets for drug development. Among them are the telomeres, DNA-protein structures that play an important role in the long term in cell cycle/survival. Telomeres are the physical ends of eukaryotic chromosomes. Due to their multiple interactions with different proteins that confer a likewise complex dynamic, they have emerged as objects of interest in many medical studies, including studies on leishmaniases. This review aims to gather information and elucidate what we know about the phenomena behind spp. telomere maintenance and how it impacts the parasite's cell cycle.

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