Melatonin Alleviates Silica Nanoparticle-Induced Lung Inflammation Via Thioredoxin-Interacting Protein Downregulation

Overview

Journal Antioxidants (Basel)

Date 2021 Nov 27

PMID 34829636

Citations 5

Authors

Je-Oh Lim

Se-Jin Lee

Woong-Il Kim

So-Won Pak

Jong-Choon Kim

Joong-Sun Kim

Young-Kwon Cho

In-Chul Lee

In-Sik Shin

Affiliations

Soon will be listed here.

Abstract

Silica dioxide nanoparticles (SiONPs) have been increasingly used in various industries; however, this has raised concerns regarding their potential toxicity. SiONPs are also a major component in the Asian sand dust that causes pulmonary diseases among the general public. Melatonin exerts some inhibitory effects against lung inflammation. In this study, we explored the therapeutic properties of melatonin against lung inflammation using an SiONPs-induced lung inflammation murine model and SiONPs-stimulated H292 cells, human airway epithelial cell line, by focusing on the involvement of thioredoxin-interacting protein (TXNIP) in the modulation of the MAPKs/AP-1 axis. We induced an inflammatory response by exposing mouse lungs and the H292 cells to SiONPs and confirmed the anti-inflammatory effect of melatonin. Melatonin inhibited the expression of various inflammatory mediators, including , , and , in SiONPs-exposed mice and SiONPs-stimulated H292 cells; this inhibition contributed to a decline in inflammatory cell accumulation in the lung tissues. Furthermore, melatonin treatment decreased the expression of MAPKs and AP-1 by downregulating TXNIP, eventually decreasing the production of SiONPs-induced inflammatory mediators. Overall, these data suggest that melatonin reduces SiONPs-induced lung inflammation by downregulating the TXNIP/MAPKs/AP-1 signalling pathway, thereby supporting the use of melatonin as an effective approach to control SiONPs-induced lung inflammation.

Citing Articles

Copper oxide nanoparticles exacerbate chronic obstructive pulmonary disease by activating the TXNIP-NLRP3 signaling pathway.

Kim W, Pak S, Lee S, Park S, Lim J, Kim D Part Fibre Toxicol. 2024; 21(1):46.

PMID: 39529109 PMC: 11552314. DOI: 10.1186/s12989-024-00608-3.

TXNIP regulates pulmonary inflammation induced by Asian sand dust.

Pak S, Kim W, Lee S, Park S, Cho Y, Kim J Redox Biol. 2024; 78:103421.

PMID: 39520910 PMC: 11671764. DOI: 10.1016/j.redox.2024.103421.

Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly.

Gong M, Zhang H, Lou M, Wang Y, Ma R, Hu Z Immun Inflamm Dis. 2023; 11(2):e788.

PMID: 36840497 PMC: 9933203. DOI: 10.1002/iid3.788.

Exposure to China dust exacerbates testicular toxicity induced by cyclophosphamide in mice.

Kim W, Lim J, Pak S, Lee S, Shin I, Moon C Toxicol Res. 2023; 39(1):115-125.

PMID: 36726831 PMC: 9839921. DOI: 10.1007/s43188-022-00149-x.

Oxidative Stress and Inflammatory Biomarkers for Populations with Occupational Exposure to Nanomaterials: A Systematic Review and Meta-Analysis.

Luo X, Xie D, Hu J, Su J, Xue Z Antioxidants (Basel). 2022; 11(11).

PMID: 36358554 PMC: 9687069. DOI: 10.3390/antiox11112182.

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