Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Nov 27

PMID 34827262

Authors

Sukitha Geethma Kothalawala

Jun Zhang

Yue Wang

Chengzhong Yu

Affiliations

Soon will be listed here.

Abstract

Oregano essential oil (OEO) is a natural compound consisting of potent antibiotic molecules. Its volatility is the major obstacle against the transportation and anti-bacterial performance. In this work, submicron-sized vermiculite (SMV) particles were prepared from Australian vermiculite clay by ball milling, and tested as a potential particulate-carrier for OEO. The loading of OEO by SMV can be easily achieved by mechanical mixing. Compared to raw vermiculite and free OEO, the OEO-loaded SMV displayed sustained isothermal release behaviour of OEO and demonstrated enhanced antibacterial performance in in vitro antibacterial tests against () and   (). This study provides a facile and commercially viable approach in designing advantageous carriers for volatile actives in antimicrobial applications.

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