Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2021 Nov 27

PMID 34827138

Citations 13

Authors

J Francis Borgio

Alia Saeed Rasdan

Bayan Sonbol

Galyah Alhamid

Noor B Almandil

Sayed AbdulAzeez

Affiliations

Soon will be listed here.

Abstract

We aimed to identify the prevalence and emerging status of multidrug-resistant bacteria and fungi and their associated mortality in nine countries in the Arabian Peninsula. Original research articles and case studies regarding multidrug-resistant bacteria and fungi in the Arabian Peninsula, published during the last 10 years, were retrieved from PubMed and Scopus. A total of 382 studies were included as per the inclusion and exclusion criteria, as well as the PRISMA guidelines, from a thorough screening of 1705 articles, in order to analyse the emerging status and mortality. The emerging nature of >120 multidrug-resistant (MDR) bacteria and fungi in the Arabian Peninsula is a serious concern that requires continuous monitoring and immediate preventive measures. More than 50% ( = 453) of multidrug-resistant, microbe-associated mortality ( = 871) in the Arabian Peninsula was due to MDR and infection. Overall, a 16.51% mortality was reported among MDR-infected patients in the Arabian Peninsula from the 382 articles of this registered systematic review. MDR (5600 isolates) prevailed in all the nine countries of the Arabian Peninsula and was one of the fastest emerging MDR bacteria with the highest mortality ( = 210). A total of 13,087 isolates were reported in the region. (580 strains) is the most prevalent among the MDR fungal pathogen in the Arabian Peninsula, having caused 54 mortalities. Active surveillance, constant monitoring, the development of a candidate vaccine, an early diagnosis of MDR infection, the elimination of multidrug resistance modulators and uninterrupted preventive measures with enhanced data sharing are mandatory to control MDR infection and associated diseases of the Arabian Peninsula. Accurate and rapid detection methods are needed to differentiate MDR strain from other strains of the species. This review summarises the logical relation, prevalence, emerging status and associated mortality of MDR microbes in the Arabian Peninsula.

Citing Articles

Genome-Guided Identification of Surfactin-Producing AQ11M9 with Anti- Potential.

Borgio J, Alhujaily R, Alfaraj A, Alabdullah M, Alaqeel R, Kaabi A Int J Mol Sci. 2024; 25(19).

PMID: 39408762 PMC: 11476397. DOI: 10.3390/ijms251910408.

Role of ERG11 and MDR1 genes in cycloheximide and multidrug resistance in Candida species.

Huma Z, Saleem S, Imran M, Raza S, Jabeen K, Arshad F Braz J Microbiol. 2024; 55(3):2569-2579.

PMID: 38980650 PMC: 11405649. DOI: 10.1007/s42770-024-01436-5.

The Potential of Dutasteride for Treating Multidrug-Resistant Infection.

Borgio J, Almandil N, Selvaraj P, John J, Alquwaie R, AlHasani E Pharmaceutics. 2024; 16(6).

PMID: 38931930 PMC: 11207579. DOI: 10.3390/pharmaceutics16060810.

The Rapidly Changing Patterns in Bacterial Co-Infections Reveal Peaks in Limited Gram Negatives during COVID-19 and Their Sharp Drop Post-Vaccination, Implying Potential Evolution of Co-Protection during Vaccine-Virus-Bacterial Interplay.

Said K, Alsolami A, Alshammari K, Moussa S, Alshammeri F, Alghozwi M Viruses. 2024; 16(2).

PMID: 38400003 PMC: 10893479. DOI: 10.3390/v16020227.

Antimicrobial potential of Streptomyces coeruleofuscus SCJ isolated from microbiologically unexplored garden soil in Northwest Morocco.

Rammali S, Rahim A, El Aalaoui M, Bencharki B, Dari K, Habach A Sci Rep. 2024; 14(1):3359.

PMID: 38336871 PMC: 10858231. DOI: 10.1038/s41598-024-53801-x.

References

Khan R, Al-Dorzi H, Tamim H, Rishu A, Balkhy H, El-Saed A . The impact of onset time on the isolated pathogens and outcomes in ventilator associated pneumonia. J Infect Public Health. 2015; 9(2):161-71. DOI: 10.1016/j.jiph.2015.09.002. View

Sambas M, Rabbani U, Al-Gethamy M, Surbaya S, Alharbi F, Ahmad R . Prevalence and Determinants of Multidrug-Resistant Tuberculosis in Makkah, Saudi Arabia. Infect Drug Resist. 2020; 13:4031-4038. PMC: 7667158. DOI: 10.2147/IDR.S277477. View

Abdel-Halim H, Al Dajani A, Abdelhalim A, Abdelmalek S . The search of potential inhibitors of the AcrAB-TolC system of multidrug-resistant Escherichia coli: an in silico approach. Appl Microbiol Biotechnol. 2019; 103(15):6309-6318. DOI: 10.1007/s00253-019-09954-1. View

Taha M, Homeida H, Dafalla O, Abdelwahab S . Multidrug resistance, prevalence and phylogenetic analysis of genes encoding class II and III integrons in clinically isolated Escherichia coli. Cell Mol Biol (Noisy-le-grand). 2018; 64(5):122-126. View

Abdalla N, Osman A, Haimour W, Sarhan M, Mohammed M, Zyad E . Antimicrobial susceptibility pattern in nosocomial infections caused by Acinetobacter species in Asir Region, Saudi Arabia. Pak J Biol Sci. 2014; 16(6):275-80. DOI: 10.3923/pjbs.2013.275.280. View

Aly M, Abu Alsoud N, Elrobh M, Al Johani S, Balkhy H . High prevalence of the PER-1 gene among carbapenem-resistant Acinetobacter baumannii in Riyadh, Saudi Arabia. Eur J Clin Microbiol Infect Dis. 2016; 35(11):1759-1766. DOI: 10.1007/s10096-016-2723-8. View

Leangapichart T, Gautret P, Griffiths K, Belhouchat K, Memish Z, Raoult D . Acquisition of a High Diversity of Bacteria during the Hajj Pilgrimage, Including Acinetobacter baumannii with blaOXA-72 and Escherichia coli with blaNDM-5 Carbapenemase Genes. Antimicrob Agents Chemother. 2016; 60(10):5942-8. PMC: 5038294. DOI: 10.1128/AAC.00669-16. View

Khan Z, Ahmad S, Al-Sweih N, Joseph L, Alfouzan W, Asadzadeh M . Increasing prevalence, molecular characterization and antifungal drug susceptibility of serial Candida auris isolates in Kuwait. PLoS One. 2018; 13(4):e0195743. PMC: 5891028. DOI: 10.1371/journal.pone.0195743. View

Al-Qahtani A, Al-Agamy M, Ali M, Al-Ahdal M, Aljohi M, Shibl A . Characterization of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae from Riyadh, Saudi Arabia. J Chemother. 2013; 26(3):139-45. DOI: 10.1179/1973947813Y.0000000124. View

10.

Bin Thani A . Characterization of previously identified novel DNA fragment associated with Pathogenicity Island III reveals new bla gene. Infect Genet Evol. 2019; 75:103971. DOI: 10.1016/j.meegid.2019.103971. View

11.

Mokaddas E, Ahmad S, Eldeen H, Al-Mutairi N . Discordance between Xpert MTB/RIF assay and Bactec MGIT 960 Culture System for detection of rifampin-resistant Mycobacterium tuberculosis isolates in a country with a low tuberculosis (TB) incidence. J Clin Microbiol. 2015; 53(4):1351-4. PMC: 4365205. DOI: 10.1128/JCM.03412-14. View

12.

Alateah S, Othman M, Ahmed M, Al Amro M, Al Sherbini N, Ajlan H . A retrospective study of tuberculosis prevalence amongst patients attending a tertiary hospital in Riyadh, Saudi Arabia. J Clin Tuberc Other Mycobact Dis. 2020; 21:100185. PMC: 7527716. DOI: 10.1016/j.jctube.2020.100185. View

13.

Elshafie S, Taj-Aldeen S . Emerging resistant serotypes of invasive Streptococcus pneumoniae. Infect Drug Resist. 2016; 9:153-60. PMC: 4935045. DOI: 10.2147/IDR.S102410. View

14.

Vijayakumar R, Sandle T, Al-Aboody M, AlFonaisan M, Alturaiki W, Mickymaray S . Distribution of biocide resistant genes and biocides susceptibility in multidrug-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii - A first report from the Kingdom of Saudi Arabia. J Infect Public Health. 2018; 11(6):812-816. DOI: 10.1016/j.jiph.2018.05.011. View

15.

Olaitan A, Dia N, Gautret P, Benkouiten S, Belhouchat K, Drali T . Acquisition of extended-spectrum cephalosporin- and colistin-resistant Salmonella enterica subsp. enterica serotype Newport by pilgrims during Hajj. Int J Antimicrob Agents. 2015; 45(6):600-4. DOI: 10.1016/j.ijantimicag.2015.01.010. View

16.

Mechkarska M, Prajeep M, Radosavljevic G, Jovanovic I, Al Baloushi A, Sonnevend A . An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties. Peptides. 2013; 50:153-9. DOI: 10.1016/j.peptides.2013.10.015. View

17.

AlJindan R, AlEraky D, Borgio J, AbdulAzeez S, Abdalhamid B, Mahmoud N . Diagnostic deficiencies of infection among patients in a tertiary hospital in Saudi Arabia: A laboratory-based case series. Saudi J Biol Sci. 2021; 28(8):4472-4477. PMC: 8324924. DOI: 10.1016/j.sjbs.2021.04.044. View

18.

Lesho E, Lin X, Clifford R, Snesrud E, Onmus-Leone F, Appalla L . From the Battlefield to the Bedside: Supporting Warfighter and Civilian Health With the "ART" of Whole Genome Sequencing for Antibiotic Resistance and Outbreak Investigations. Mil Med. 2016; 181(7):621-4. DOI: 10.7205/MILMED-D-15-00197. View

19.

Algowaihi R, Ashgar S, Sirag B, Shalam S, Nassir A, Ahmed A . Draft Genome Sequence of a Multidrug-Resistant Klebsiella pneumoniae Strain Isolated from King Abdullah Medical City, Makkah, Saudi Arabia. Genome Announc. 2016; 4(3). PMC: 4889002. DOI: 10.1128/genomeA.00375-16. View

20.

Ahmed A, A Salih F . Low concentrations of local honey modulate Exotoxin A expression, and quorum sensing related virulence in drug-resistant recovered from infected burn wounds. Iran J Basic Med Sci. 2019; 22(5):568-575. PMC: 6556501. DOI: 10.22038/ijbms.2019.33077.7902. View