» Articles » PMID: 348265

Phagocytosis and Killing of Bacteria and Yeast by Human Milk Cells After Opsonisation in Aqueous Phase of Milk

Overview
Journal Br Med J
Specialty General Medicine
Date 1978 Jun 3
PMID 348265
Citations 10
Authors
Affiliations
Soon will be listed here.
Abstract

Macrophages and neutrophils from human milk phagocytose and kill Staphylococcus aureus and Escherichia coli in vitro after opsonisation by the aqueous phase of milk as effectively as blood leucocytes in serum. They also phagocytose Candida albicans. The overgrowth of E coli resulting from the addition of iron to cultures of the organism in the aqueous phase of milk is not influenced by the presence of cells. We conclude that the phagocytosis and killing of bacteria by milk cells may contribute to the lower incidence of infection among breast-fed than artificially fed babies.

Citing Articles

The contributions of parental lactation on offspring development: It's not udder nonsense!.

Wijenayake S, Martz J, Lapp H, Storm J, Champagne F, Kentner A Horm Behav. 2023; 153:105375.

PMID: 37269591 PMC: 10351876. DOI: 10.1016/j.yhbeh.2023.105375.


Immunomodulatory Effects of Bacterial Toll-like Receptor Ligands on the Phenotype and Function of Milk Immune Cells in Dromedary Camel.

Hussen J, Alkuwayti M, Falemban B, Al-Sukruwah M, Alhojaily S, Humam N Biology (Basel). 2023; 12(2).

PMID: 36829554 PMC: 9952959. DOI: 10.3390/biology12020276.


Role of Prolactin in Promotion of Immune Cell Migration into the Mammary Gland.

Dill R, Walker A J Mammary Gland Biol Neoplasia. 2016; 22(1):13-26.

PMID: 27900586 PMC: 5313375. DOI: 10.1007/s10911-016-9369-0.


Macrophages in resistance to candidiasis.

Vazquez-Torres A, Balish E Microbiol Mol Biol Rev. 1997; 61(2):170-92.

PMID: 9184009 PMC: 232606. DOI: 10.1128/mmbr.61.2.170-192.1997.


Neutralizing activity against Clostridium difficile toxin in the supernatants of cultured colostral cells.

Wada N, Nishida N, Iwaki S, Ohi H, Miyawaki T, Taniguchi N Infect Immun. 1980; 29(2):545-50.

PMID: 7216424 PMC: 551153. DOI: 10.1128/iai.29.2.545-550.1980.


References
1.
Smith C, Goldman A . The cells of human colostrum. I. In vitro studies of morphology and functions. Pediatr Res. 1968; 2(2):103-9. DOI: 10.1203/00006450-196803000-00005. View

2.
Lehrer R, Cline M . Interaction of Candida albicans with human leukocytes and serum. J Bacteriol. 1969; 98(3):996-1004. PMC: 315286. DOI: 10.1128/jb.98.3.996-1004.1969. View

3.
Ammann A, Stiehm E . Immune globulin levels in colostrum and breast milk, and serum from formula- and breast-fed newborns. Proc Soc Exp Biol Med. 1966; 122(4):1098-100. DOI: 10.3181/00379727-122-31335. View

4.
Paape M, Schultze W, Miller R . Leukocytic response to adrenocorticotrophic hormone as influenced by the infectious history of the mammary gland. J Dairy Sci. 1973; 56(6):733-7. DOI: 10.3168/jds.S0022-0302(73)85242-7. View

5.
Hanson L, Winberg J . Breast milk and defence against infection in the newborn. Arch Dis Child. 1972; 47(256):845-8. PMC: 1648417. DOI: 10.1136/adc.47.256.845. View