Personal Metabolomics: A Global Challenge

Overview

Journal Metabolites

Publisher MDPI

Date 2021 Nov 25

PMID 34822372

Citations 4

Authors

Petr G Lokhov

Oxana P Trifonova

Dmitry L Maslov

Steven Lichtenberg

Elena E Balashova

Affiliations

Soon will be listed here.

Abstract

Today, the introduction of metabolomics, like other omics sciences, into clinical practice as a personal omics test that realizes the perfect analytical capabilities of this science has become an important subject. The assembled data show that the metabolome of biosamples is a collection of highly informative and accurate signatures of virtually all diseases that are widespread in the population. However, we have not seen the emergence of personalized metabolomics in clinical practice. This article analyzes the causes of this problem. The complexity of personal metabolic data analysis and its incompatibility with widely accepted data treatment in metabolomics are shown. As a result, the impossibility of translating metabolic signatures accumulated in databases into a personal test is revealed. Problem-solving strategies that may radically change the situation and realize the analytical capabilities of metabolomics in medical laboratory practice are discussed.

Citing Articles

Application of clinical blood metabogram for diagnosis of early-stage Parkinson's disease: a pilot study.

Lokhov P, Trifonova O, Balashova E, Maslov D, Ugrumov M, Archakov A Front Mol Biosci. 2024; 11:1407974.

PMID: 39206052 PMC: 11350164. DOI: 10.3389/fmolb.2024.1407974.

Linking Clinical Blood Metabogram and Gut Microbiota.

Lokhov P, Balashova E, Maslov D, Trifonova O, Lisitsa A, Markova Y Metabolites. 2023; 13(10).

PMID: 37887420 PMC: 10609303. DOI: 10.3390/metabo13101095.

Current State and Future Perspectives on Personalized Metabolomics.

Trifonova O, Maslov D, Balashova E, Lokhov P Metabolites. 2023; 13(1).

PMID: 36676992 PMC: 9863827. DOI: 10.3390/metabo13010067.

Mass Spectrometric Blood Metabogram: Acquisition, Characterization, and Prospects for Application.

Lokhov P, Balashova E, Trifonova O, Maslov D, Grigoriev A, Ponomarenko E Int J Mol Sci. 2023; 24(2).

PMID: 36675249 PMC: 9861083. DOI: 10.3390/ijms24021736.

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