Evaluation of Pretreatment Magnetic Resonance Elastography for the Prediction of Radiation-Induced Liver Disease

Overview

Journal Adv Radiat Oncol

Specialty Oncology

Date 2021 Nov 25

PMID 34820550

Citations 1

Authors

Trey C Mullikin

Kay M Pepin

Jaden E Evans

Sudhakar K Venkatesh

Richard L Ehman

Kenneth W Merrell

Michael G Haddock

William S Harmsen

Michael G Herman

Christopher L Hallemeier

Affiliations

Soon will be listed here.

Abstract

Purpose: Magnetic resonance (MR) elastography (E) is a noninvasive technique for quantifying liver stiffness (LS) for fibrosis. This study evaluates whether LS is associated with risk of developing radiation-induced liver disease (RILD) in patients receiving liver-directed radiation therapy (RT).

Methods And Materials: Based on prior studies, LS ≤3 kPa was considered normal and LS >3.0 kPa as representing fibrosis. RILD was defined as an increase in Child-Pugh (CP) score of ≥2 from baseline within 1 year of RT. Univariate and multivariate Cox models were used to assess correlation.

Results: One hundred two patients, 51 with primary liver tumors and 51 with liver metastases, were identified with sufficient follow-up. In univariate models, pre-RT LS >3.0 kPa (hazard ratio [HR] 4.9; 95% confidence interval [CI], 1.6-14; = .004), body mass index (BMI), clinical cirrhosis, CP score, albumin-bilirubin (ALBI) grade 2, primary liver tumor, and mean liver dose were significantly associated with risk of post-RT RILD. In a multivariate analysis, LS >3.0 and mean liver dose both were significantly associated with RILD risk.

Conclusions: Elevated pre-RT LS is associated with an increased risk of RILD in patients receiving liver-directed RT.

Citing Articles

Assessing four-dimensional CT stress maps derived from patient-specific biomechanical models of the lung with pulmonary function test data in lung cancer patients.

Shiinoki T, Fujimoto K, Kawazoe Y, Yuasa Y, Kajima M, Manabe Y Br J Radiol. 2023; 96(1149):20221149.

PMID: 37393529 PMC: 10461275. DOI: 10.1259/bjr.20221149.

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