The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Nov 22

PMID 34804951

Citations 25

Authors

Zhigang Li

Qingyu Guo

Jiaxin Zhang

Zitong Fu

Yifei Wang

Tianzhen Wang

Jing Tang

Affiliations

Soon will be listed here.

Abstract

The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs. RBM proteins are involved in RNA metabolism, including splicing, transport, translation, and stability. Many studies have found that aberrant expression and dysregulated function of RBM proteins family members are closely related to the occurrence and development of cancers. This review summarizes the role of RBM proteins family genes in cancers, including their roles in cancer occurrence and cell proliferation, migration, and apoptosis. It is essential to understand the mechanisms of these proteins in tumorigenesis and development, and to identify new therapeutic targets and prognostic markers.

Citing Articles

The Oncopromoting Gene RBM6 Inhibits Prostate Tumour Cell Migration During Epithelial-to-Mesenchymal Transition.

Liu R, Liu Y, Zhang L, Li X, Li N, Lu F J Cell Mol Med. 2025; 29(3):e70397.

PMID: 39900560 PMC: 11790351. DOI: 10.1111/jcmm.70397.

RBM19 promotes the progression of prostate cancer under docetaxel treatment via SNHG21/PIM1 axis.

Zhuang W, Xu S, He Q, Su Q, Chen H, Chen J Cell Biol Toxicol. 2024; 41(1):19.

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Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma.

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Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis.

Liang Y, Zhong H, Zhao Y, Tang X, Pan C, Sun J Biol Direct. 2024; 19(1):57.

PMID: 39039611 PMC: 11264397. DOI: 10.1186/s13062-024-00499-6.

RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway.

Huang F, Dai Z, Yu J, Wang K, Chen C, Chen D Elife. 2024; 13.

PMID: 38995840 PMC: 11245308. DOI: 10.7554/eLife.95318.

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