Neuroprotective Effects of in a Mouse Model of Pentylenetetrazole-induced Seizures

Overview

Journal Avicenna J Phytomed

Publisher Mashhad University of Medical Sciences

Date 2021 Nov 22

PMID 34804898

Citations 4

Authors

Somaieh Mansouri

Mahmoud Hosseini

Farimah Beheshti

Mohammad-Ali Sobhanifar

Hassan Rakhshandeh

Akbar Anaeigoudari

Affiliations

Soon will be listed here.

Abstract

Objective: Oxidative stress has pernicious effects on the brain. has antioxidant properties. We explored neuroprotective effect of against pentylenetetrazole (PTZ)-induced seizures.

Materials And Methods: Male mice (BALB/c) were grouped as control, PTZ, Soxhlet (Sox) 100, Sox 200, Macerated (Mac) 100 and Mac 200 groups. Sox and Mac extracts (100 and 200 mg/kg) were injected during 7 days. Delay in onset of minimal clonic seizure (MCS) and generalized tonic- clonic seizure (GTCS) was measured. Number of dark neurons (DN) and levels of oxidative stress indicators in the hippocampus were evaluated.

Results: Onset of MCS and GTCS was later in groups treated with the extracts than the PTZ group (p<0.01 and p<0.001). Number of DN in the hippocampus in the PTZ group was higher than the control group (p<0.001) while in the extract groups, was lower than the PTZ group (p<0.05, p<0.01 and p<0.001). MDA level was higher whereas total thiol level and activity of SOD and CAT were lower (p<0.001) in the PTZ group than the control group. MDA level in the Sox 100 (p<0.01), Sox 200 (p<0.001) and Mac 200 (p<0.01) groups was less than the PTZ group. Total thiol level in the Sox 200 (p<0.001), SOD in the Sox 100 (p<0.05), Sox 200, and Mac 200 and CAT in the Sox 200 (p<0.001) groups were higher than the PTZ group.

Conclusion: prevented neuronal death and reduced seizures caused by PTZ via improving brain oxidative stress.

Citing Articles

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Neuroprotective effects of the fractions of in seizures induced by pentylenetetrazole in mice.

Mansouri S, Hosseini M, Alipour F, Beheshti F, Rakhshandeh H, Mohammadipour A Avicenna J Phytomed. 2022; 12(6):614-626.

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PPARγ activation improved learning and memory and attenuated oxidative stress in the hippocampus and cortex of aged rats.

Beheshti F, Gholami M, Ghane Z, Nazari S, Salari M, Shabab S Physiol Rep. 2022; 10(24):e15538.

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Labdane-type Diterpenes from Needles and Their Anti- Activity.

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