Chemerin-Derived Peptide Val-Pro Is Effective in Limiting Methicillin-Resistant Skin Infection

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2021 Nov 22

PMID 34803962

Citations 4

Authors

Aneta Zegar

Urszula Godlewska

Dorota Kozlowska-Chmielewska

Pawel Majewski

Brian A Zabel

Joanna Cichy

Affiliations

Soon will be listed here.

Abstract

Chemerin-derived peptide Val-Pro (p4) restricts the growth of a variety of skin-associated bacteria, including methicillin-resistant (MRSA). To better understand the antimicrobial potential of chemerin peptide, we compared p4 activity against MRSA to cathelicidin LL-37, one of the key endogenous peptides implicated in controlling the growth of . The efficacy of p4 was also validated in relevant experimental models of skin pathology, such as topical skin infection with community-acquired MRSA, and in the context of skin inflammatory diseases commonly associated with colonization with , such as atopic dermatitis (AD). We showed that p4 collaborates additively with LL-37 in inhibiting the growth of , including MRSA, and that p4 was effective in reducing MRSA burden. p4 was also effective in reducing levels of skin-infiltrating leukocytes in -infected AD-like skin. Taken together, our data suggest that p4 is effective in limiting and, in particular, MRSA skin infection.

Citing Articles

A Cross-Sectional Study: Systematic Quantification of Chemerin in Human Cerebrospinal Fluid.

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The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.

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