Molecular Strategies for Intensity-Dependent Olfactory Processing in

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2021 Nov 22

PMID 34803606

Citations 5

Authors

Hankui Cheng

Yu Liu

Yadan Xue

Jiajie Shao

Zhibing Tan

Siyan Liu

Shumin Duan

Lijun Kang

Affiliations

Soon will be listed here.

Abstract

Various odorants trigger complex animal behaviors across species in both quality- and quantity-dependent manners. However, how the intensity of olfactory input is encoded remains largely unknown. Here we report that isoamyl alcohol (IAA) induces bi-directional currents through a Gα- guanylate cyclase (GC)- cGMP signaling pathway in olfactory neuron amphid wing "C" cell (AWC), while two opposite cGMP signaling pathways are responsible for odor-sensing in olfactory neuron amphid wing "B" cell (AWB): (1) a depolarizing Gα (GPA-3)- phosphodiesterase (PDE) - cGMP pathway which can be activated by low concentrations of isoamyl alcohol (IAA), and (2) a hyperpolarizing Gα (ODR-3)- GC- cGMP pathway sensing high concentrations of IAA. Besides, IAA induces Gα (ODR-3)-TRPV(OSM-9)-dependent currents in amphid wing "A" cell (AWA) and amphid neuron "H" cell with single ciliated sensory ending (ASH) neurons with different thresholds. Our results demonstrate that an elaborate combination of multiple signaling machineries encode the intensity of olfactory input, shedding light on understanding the molecular strategies on sensory transduction.

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