Anticancer Effects and Lysosomal Acidification in A549 Cells by Astaxanthin from Haematococcus Lacustris

Overview

Journal Bioinformation

Specialty Biology

Date 2021 Nov 22

PMID 34803274

Citations 3

Authors

K Ramamoorthy

Subramanian Raghunandhakumar

R S Anand

A Paramasivam

S Kamaraj

S Nagaraj

Devaraj Ezhilarasan

Thangavelu Lakshmi

Kamal Dua

Dinesh Kumar Chellappan

Ashokkumar Veeramuthu

Affiliations

Soon will be listed here.

Abstract

Astaxanthin (AXN) is known to have health benefits by epidemiological studies. Therefore, it is of interest to assess the effect of AXN (derived from indigenous unicellular green alga Haematococcus lacustris) to modulate cell cycle arrest, lysosomal acidification and eventually apoptosis using in vitro in A549 lung cancer cells. Natural extracts of astaxanthin were obtained by standardized methods as reported earlier and characterized by standard HPLC and MS. Treatment of A549 cells with AXN (purified fraction) showed significant reduction in cell viability (about 50%) as compared to crude extract at 50µM concentration. Thus, we show the anticancer effects and lysosomal acidification in A549 cells by Astaxanthin from Haematococcus lacustris for further consideration. Together, our results demonstrated the anticancer potential of AXN from Haematococcus lacustris, which is found to be mediated via its ability to induce cell cycle arrest, lysosomal acidification and apoptotic induction.

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