Persistent Expression of Recipient-type ABH Antigen After ABO-incompatible Allogeneic Hematopoietic Stem Cell Transplantation

Overview

Journal Intern Med

Specialty General Medicine

Date 2021 Nov 22

PMID 34803100

Citations 1

Authors

Yukiko Misaki

Shinichi Kako

Shunto Kawamura

Junko Takeshita

Nozomu Yoshino

Kazuki Yoshimura

Ayumi Gomyo

Yu Akahoshi

Masaharu Tamaki

Machiko Kusuda

Kazuaki Kameda

Hidenori Wada

Koji Kawamura

Miki Sato

Kiriko Terasako-Saito

Shun-Ichi Kimura

Hideki Nakasone

Koji Kishino

Kazuo Muroi

Yoshinobu Kanda

Affiliations

Soon will be listed here.

Abstract

In general, the recipient's ABO blood type changes to the donor's ABO blood type after ABO-incompatible allogeneic hematopoietic stem cell transplantation (HSCT). However, we experienced a 26-year-old male with acute myelogenous leukemia (AML) who underwent ABO-incompatible HSCT twice and persistently showed his original blood type even after demonstrating complete donor-type chimerism. Based on the results of various examinations, we considered that the antigen of the recipient's original blood type persistently synthesized in the recipient's non-hematopoietic organs was secreted and adsorbed on the surface of donor-derived RBCs. We should therefore perform detailed examinations to determine the precise blood type after ABO-incompatible HSCT.

Citing Articles

Persistent Antigen A after Minor ABO-Incompatible Hematopoietic Stem Cell Transplantation in Children: Two Case Reports.

Andric B, Radonjic Z, Serbic O, Vujic D, Zecevic Z, Simic M Transfus Med Hemother. 2024; 51(6):439-443.

PMID: 39664456 PMC: 11630906. DOI: 10.1159/000536176.

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