Role of NRF2 and Sirtuin Activators in COVID-19

Overview

Journal Clin Immunol

Specialty Allergy & Immunology

Date 2021 Nov 19

PMID 34798239

Citations 12

Authors

Hasnat Khan

Shivangi Patel

Anuradha Majumdar

Affiliations

Soon will be listed here.

Abstract

COVID-19 is a pandemic requiring immediate solution for treatment because of its complex pathophysiology. Exploration of novel targets and thus treatment will be life savers which is the need of the hour. 2 host factors- TMPRSS2 and ACE2 are responsible for the way the virus will enter and replicate in the host. Also NRF2 is an important protein responsible for its anti-inflammatory role by multiple mechanisms of action like inhibition of NF-kB, suppression of pro-inflammatory genes, etc. NRF2 is deacetylated by Sirtuins and therefore both have a direct association. Absence of SIRT indicates inhibition of NRF2 expression and thus no anti-oxidative and anti-inflammatory protection for the cell. Therefore, we propose that NRF2 activators and/or SIRT activators can be evaluated to check their efficacy in ameliorating the symptoms of COVID-19.

Citing Articles

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The Role of the NRF2 Pathway in the Pathogenesis of Viral Respiratory Infections.

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